Oxidatively modified lipoproteins have been implicated in atherogenesis, but the mechanisms
that promote oxidation in vivo have not been identified. Myeloperoxidase, a heme protein …

Background— Hypercholesterolemia-induced atherosclerosis is attenuated by either
pharmacological antagonism of AT 1 receptors or AT 1A receptor deficiency. However, the …

Infusion of ANG II in hyperlipidemic mice augments atherosclerosis and causes formation of
abdominal aortic aneurysms (AAAs). The purpose of this study was to define the contribution …

The role of the renin angiotensin system (RAS) in atherosclerosis is complex because of the
involvement of multiple peptides and receptors. Renin is the rate-limiting enzyme in the …

AngII (angiotensin II) induces atherosclerosis and AAAs (abdominal aortic aneurysms)
through multiple proposed mechanisms, including chemotaxis. Therefore, we determined the …

Angiotensin II (AngII) infusion initiates abdominal aortic aneurysm (AAA) development due
to medial disruption and results in luminal dilation and thrombus formation. The objective of …

Aneurysms are common in the abdominal and thoracic regions of the aorta. While generally
asymptomatic, progression of aneurysms is associated with the devastating consequences …

… a,b ; Rateri, Debra L. b ; Daugherty, Alan b,c … Davis FM, Rateri DL, Daugherty A.
Mechanisms of aortic aneurysm formation: translating preclinical studies into clinical therapies …

Rationale: Human studies and mouse models have provided evidence for angiotensin II (Ang
II)–based mechanisms as an underlying cause of aneurysms localized to the ascending …

Objective— Natural killer (NK) cells are a key component of innate immunity. Despite being
identified in human and mouse atherosclerotic lesions, the role of NK cells in the disease …