While brain atrophy occurs early in the clinical course of multiple sclerosis, exactly how early,
which tissues are affected and the rate at which early atrophy occurs are unclear. Regional …

Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new treatments…

Purpose: To develop an automated lesion‐filling technique (LEAP; LEsion Automated
Preprocessing) that would reduce lesion‐associated brain tissue segmentation bias (which is …

MRI studies have provided valuable insights into the structure and function of neural networks,
particularly in health and in classical neurodegenerative conditions such as Alzheimer …

Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We
investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with …

Objective To determine whether brain atrophy and lesion volumes predict subsequent 10
year clinical evolution in multiple sclerosis (MS). Design From eight MAGNIMS (MAGNetic …

Clinically isolated syndrome (CIS) is a term that describes a first clinical episode with features
suggestive of multiple sclerosis (MS). It usually occurs in young adults and affects optic …

Objective To determine the relation of gray matter (GM) and white matter (WM) brain volumes,
and WM lesion load, with clinical outcomes 20 years after first presentation with clinically …

Before meaningful conclusions can be drawn from clinical measures of cerebral blood
perfusion, the precision of the measurement must be determined and set in the context of inter‐ …

See Stankoff and Louapre (doi: 10.1093/brain/awy114 ) for a scientific commentary on this
article. Grey matter atrophy is present from the earliest stages of multiple sclerosis, but its …