Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the
cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects …

Detailed information about stage-specific changes in gene expression is crucial for
understanding the gene regulatory networks underlying development and the various signal …

Osteoarthritis (OA) is the most common joint disease, affecting over 300 million people world-wide.
Accumulating evidence attests to the important roles of the immune system in OA …

Type 1 diabetes mellitus (T1DM) patients have osteopenia and impaired fracture healing
due to decreased osteoblast activity. Further, no adequate treatments are currently available …

Fracture healing involves rapid stem and progenitor cell migration, homing, and differentiation.
SDF‐1 (CXCL12) is considered a master regulator of CXCR4‐positive stem and …

Patients with anterior cruciate ligament (ACL) rupture are two times as likely to develop
posttraumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the United …

Joint injury causes post‐traumatic osteoarthritis (PTOA). About ∼50% of patients rupturing
their anterior cruciate ligament (ACL) will develop PTOA within 1–2 decades of the injury, yet …

Wnt signaling is critical for skeletal development and homeostasis. Sclerostin (Sost) has
emerged as a potent inhibitor of Wnt signaling and, thereby, bone formation. Thus, strategies to …

Osteoarthritis (OA) is a debilitating and painful disease characterized by the progressive loss
of articular cartilage. Post‐traumatic osteoarthritis (PTOA) is an injury‐induced type of OA …

We have used cationic liposomes to facilitate adeno-associated virus (AAV) plasmid
transfections of primary and cultured cell types. AAV plasmid DNA complexed with liposomes …