Super-resolution imaging reveals that AMPA receptors inside synapses are dynamically organized in nanodomains regulated by PSD95
The spatiotemporal organization of neurotransmitter receptors in postsynaptic membranes is
a fundamental determinant of synaptic transmission and information processing by the brain…
a fundamental determinant of synaptic transmission and information processing by the brain…
Heterogeneity of AMPA receptor trafficking and molecular interactions revealed by superresolution analysis of live cell imaging
Simultaneous tracking of many thousands of individual particles in live cells is possible now
with the advent of high-density superresolution imaging methods. We present an approach …
with the advent of high-density superresolution imaging methods. We present an approach …
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
Integrins in focal adhesions (FAs) mediate adhesion and force transmission to extracellular
matrices essential for cell motility, proliferation and differentiation. Different fibronectin-…
matrices essential for cell motility, proliferation and differentiation. Different fibronectin-…
Replication by human DNA polymerase-ι occurs by Hoogsteen base-pairing
DT Nair, RE Johnson, S Prakash, L Prakash… - Nature, 2004 - nature.com
Almost all DNA polymerases show a strong preference for incorporating the nucleotide that
forms the correct Watson–Crick base pair with the template base. In addition, the catalytic …
forms the correct Watson–Crick base pair with the template base. In addition, the catalytic …
[HTML][HTML] Real-time analysis and visualization for single-molecule based super-resolution microscopy
<p>Accurate multidimensional localization of isolated fluorescent emitters is a time
consuming process in single-molecule based super-resolution microscopy. We demonstrate a …
consuming process in single-molecule based super-resolution microscopy. We demonstrate a …
Fast native-SAD phasing for routine macromolecular structure determination
We describe a data collection method that uses a single crystal to solve X-ray structures by
native SAD (single-wavelength anomalous diffraction). We solved the structures of 11 real-life …
native SAD (single-wavelength anomalous diffraction). We solved the structures of 11 real-life …
Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion
A Chazeau, A Mehidi, D Nair, JJ Gautier… - The EMBO …, 2014 - embopress.org
Actin dynamics drive morphological remodeling of neuronal dendritic spines and changes
in synaptic transmission. Yet, the spatiotemporal coordination of actin regulators in spines is …
in synaptic transmission. Yet, the spatiotemporal coordination of actin regulators in spines is …
Small strokes causing severe vertigo: frequency of false-negative MRIs and nonlacunar mechanisms
… Pula and Deepak Nair: assisted in data collection, reviewed and critically edited the
manuscript, and approved the final version. Ari Blitz and Sarah Ying: assisted in data coding, …
manuscript, and approved the final version. Ari Blitz and Sarah Ying: assisted in data coding, …
Rev1 employs a novel mechanism of DNA synthesis using a protein template
DT Nair, RE Johnson, L Prakash, S Prakash… - Science, 2005 - science.org
The Rev1 DNA polymerase is highly specialized for the incorporation of C opposite template
G. We present here the crystal structure of yeast Rev1 bound to template G and incoming 2…
G. We present here the crystal structure of yeast Rev1 bound to template G and incoming 2…
[HTML][HTML] Human DNA polymerase κ encircles DNA: implications for mismatch extension and lesion bypass
…, SN Uljon, RE Johnson, A Brahma, DT Nair… - Molecular cell, 2007 - cell.com
Human DNA polymerase κ (Pol κ) is a proficient extender of mispaired primer termini on
undamaged DNAs and is implicated in the extension step of lesion bypass. We present here the …
undamaged DNAs and is implicated in the extension step of lesion bypass. We present here the …