Cellular heterogeneity and an immunosuppressive tumour microenvironment are independent
yet synergistic drivers of tumour progression and underlie therapeutic resistance. Recent …

Extracellular vesicles (EV), including exosomes and microvesicles, are nano-sized intercellular
communication vehicles that participate in a multitude of physiological processes. Due to …

Sexual dimorphism at the level of MDSC subset prevalence, localization, and gene-expression
profile constitutes a therapeutic opportunity. Our results indicate that chemotherapy can …

The transfer of intact mitochondria between heterogeneous cell types has been confirmed
in various settings, including cancer. However, the functional implications of mitochondria …

Glioblastoma (GBM) remains uniformly lethal, and despite a large accumulation of immune
cells in the microenvironment, there is limited antitumor immune response. To overcome …

Synthetic oligodeoxynucleotides that can down-regulate cellular elements of the immune
system have been developed and are being widely studied in preclinical models. These …

The application of tumor immunotherapy to glioblastoma (GBM) is limited by an unprecedented
degree of immune suppression due to factors that include high numbers of immune …

BACKGROUND Myeloid-derived suppressor cells (MDSCs) are elevated in the circulation
of patients with glioblastoma (GBM), present in tumor tissue, and associated with poor …

Recent studies reveal that lateral mitochondrial transfer, the movement of mitochondria from
one cell to another, can affect cellular and tissue homeostasis. Most of what we know about …

Restoration of the gut microbiome, which is disrupted following antibiotic treatment, may
help overcome platinum resistance in patients with epithelial ovarian cancer. See related …