Senescence is involved in various pathophysiological conditions. Besides loss of retinoblastoma
and p53 pathways, little is known about other pathways involved in senescence. Here …

Prostate cancer is a major cause of cancer-related death in American men, for which finding
new therapeutic strategies remains a challenge. Early growth response-1 (EGR1) is a …

Early growth response-1 (Egr-1) is overexpressed in human prostate tumors and contributes
to cancer progression. On the other hand, mutation of p53 is associated with advanced …

Little is known about the physiological role of the phospholipase A2 receptor (PLA2R1).
PLA2R1 has been described as regulating the replicative senescence, a telomerase-dependent …

Oxidative phosphorylation (OXPHOS) generates ROS as a byproduct of mitochondrial
complex I activity. ROS-detoxifying enzymes are made available through the activation of their …

Oncogene-induced senescence (OIS) constitutes a failsafe program that restricts tumor
development. However, the mechanisms that link oncogenesis to senescence are not completely …

Background Cohort studies suggested that individuals with higher intake of tomatoes and
tomato products have a lower risk of degenerative diseases. Lycopene, an antioxidant and …

Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes.
The anti-diabetic drug metformin modifies tumor cell metabolism and several clinical …

Controlling cholesterol levels is a major challenge in human health, since hypercholesterolemia
can lead to serious cardiovascular disease. Drugs that target carbohydrate metabolism …

RIP140 is a transcriptional coregulator (also known as NRIP1) which plays very important
physiological roles by finely tuning the activity of a large number of transcription factors. …