We measured neutrophil glucose uptake with positron emission tomographic imaging and [
18 F]fluorodeoxyglucose ([ 18 F]FDG-PET) in anesthetized dogs after intravenous oleic acid-…

A series of fluorine-containing benzamide analogs was synthesized and evaluated as candidate
ligands for positron emission tomography (PET) imaging of the sigma-2 (σ 2 ) receptor …

Imaging of poly (ADP-ribose) polymerase-1 (PARP-1) expression in vivo is a potentially
powerful tool for developing PARP-1 inhibitors for drug discovery and patient care. We have …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease
without effective molecular markers of disease activity or treatment responses. Monocyte and …

Millions of people are affected by respiratory diseases, leading to a significant health burden
globally. Because of the current insufficient knowledge of the underlying mechanisms that …

… Correspondence and requests for reprints should be addressed to Delphine L. Chen,
Department of Radiology, Washington University School of Medicine, Campus Box 8223, 660 S. …

Small nucleolar RNAs (snoRNAs) are noncoding RNAs that guide chemical modifications of
structural RNAs. Whereas snoRNAs primarily localize in the nucleolus, where their …

Purpose To demonstrate that positron emission tomography (PET) with fluorine 18 ( 18 F)
fluorthanatrace (FTT) depicts activated poly (adenosine diphosphate–ribose)polymerase (…

Recent studies indicate that a focal, limited, inflammatory response can be safely elicited
after direct bronchial instillation of small doses of endotoxin into a single lung segment. …

Purpose We tested whether positron emission tomography (PET) with the caspase-3-targeted
isatin analog [ 18 F]WC-4-116 could image caspase-3 activation in response to an …