[HTML][HTML] Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis

D Pinatel, B Hivert, J Boucraut… - Frontiers in Cellular …, 2015 - frontiersin.org
Contactin-associated protein-like 2 (Caspr2), also known as CNTNAP2, is a cell adhesion
molecule that clusters voltage-gated potassium channels (Kv1.1/1.2) at the juxtaparanodes of …

Genetic variants in autism-related CNTNAP2 impair axonal growth of cortical neurons

G Canali, M Garcia, B Hivert, D Pinatel… - Human molecular …, 2018 - academic.oup.com
The CNTNAP2 gene, coding for the cell adhesion glycoprotein Caspr2, is thought to be one
of the major susceptibility genes for autism spectrum disorder (ASD). A large number of rare …

[PDF][PDF] VEGF counteracts amyloid-β-induced synaptic dysfunction

…, N Chounlamountri, C Watrin, R Besançon, D Pinatel… - Cell reports, 2021 - cell.com
The vascular endothelial growth factor (VEGF) pathway regulates key processes in synapse
function, which are disrupted in early stages of Alzheimer's disease (AD) by toxic-soluble …

Impact of anti-CASPR2 autoantibodies from patients with autoimmune encephalitis on CASPR2/TAG-1 interaction and Kv1 expression

…, A Pieters, B Déchelotte, C Malleval, D Pinatel… - Journal of …, 2019 - Elsevier
Autoantibodies against CASPR2 (contactin-associated protein-like 2) have been linked to
autoimmune limbic encephalitis that manifests with memory disorders and temporal lobe …

The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons

D Pinatel, B Hivert, M Saint-Martin… - Journal of Cell …, 2017 - journals.biologists.com
Caspr2 and TAG-1 (also known as CNTNAP2 and CNTN2, respectively) are cell adhesion
molecules (CAMs) associated with the voltage-gated potassium channels Kv1.1 and Kv1.2 (…

[HTML][HTML] Assembly and function of the juxtaparanodal Kv1 complex in health and disease

D Pinatel, C Faivre-Sarrailh - Life, 2020 - mdpi.com
The precise axonal distribution of specific potassium channels is known to secure the shape
and frequency of action potentials in myelinated fibers. The low-threshold voltage-gated …

Assembly of juxtaparanodes in myelinating DRG culture: Differential clustering of the K v1/C aspr2 complex and scaffolding protein 4.1 B

B Hivert, D Pinatel, M Labasque, N Tricaud… - Glia, 2016 - Wiley Online Library
The precise distribution of ion channels at the nodes of Ranvier is essential for the efficient
propagation of action potentials along myelinated axons. The voltage‐gated potassium …

A class-specific effect of dysmyelination on the excitability of hippocampal interneurons

D Pinatel, E Pearlstein, G Bonetto, L Goutebroze… - Elife, 2023 - elifesciences.org
The role of myelination for axonal conduction is well-established in projection neurons but
little is known about its significance in GABAergic interneurons. Myelination is discontinuous …

Régulation de l'expression axonale de Caspr2, une molécule d'adhérence associée aux canaux potassiques Kv1

D Pinatel - 2015 - theses.fr
Caspr2 est une molécule d'adhérence impliquée dans diverses pathologies neurologiques
telles que l'autisme et l'encéphalite limbique (EL). Les mécanismes pathogéniques restent …

[PDF][PDF] VEGF counteracts amyloid-b-induced synaptic dysfunction

D Pinatel, D Meyronet, J Honnorat, A Buisson, PA Salin… - Cell Reports, 2021 - hal.science
The vascular endothelial growth factor (VEGF) pathway regulates key processes in synapse
function, which are disrupted in early stages of Alzheimer’s disease (AD) by toxic-soluble …