End binding 1 (EB1) is a plus-end-tracking protein (+TIP) that localizes to microtubule plus
ends where it modulates their dynamics and interactions with intracellular organelles 1 , 2 . …

We have used cryo-electron microscopy of vitrified specimens to study microtubules assembled
both from three cycle purified tubulin (3x-tubulin) and in cell free extracts of Xenopus …

Tubulin assembles to form a range of structures that differ by their protofilament and monomer
helix-start numbers. The microtubule lattice is believed to accommodate these different …

Observation of microtubule growth at different rates by cryo-electron microscopy reveals that
the ends range from blunt to long, gently curved sheets. The mean sheet length increases …

The absence of detailedin vitrostudies leaves the molecular events involved in the centrosome
cycle poorly characterized. Most earlier studies have employed electron microscopy of …

The in vitro polymerisation of tubulin is a remarkable example of protein self‐assembly in
thet several closely related microtubule structures coexist on the polymerisation plateau. …

We have used cryoelectron microscopy to try to understand the structural basis for the role
of GTP hydrolysis in destabilizing the microtubule lattice. We have measured a structural …

Exosomes are important mediators in intercellular communication. Released by many cell
types, they transport proteins, lipids, and nucleic acids to distant recipient cells and contribute …

Microtubules are dynamic polymers that interconvert between periods of slow growth and
fast shrinkage. The energy driving this nonequilibrium behavior comes from the hydrolysis of …

Staphylococcus aureus is a major pathogen responsible for bovine mastitis, the most
common and costly disease affecting dairy cattle. S. aureus naturally releases extracellular …