User profiles for Denis E. Kainov
Denis KainovVerified email at helsinki.fi Cited by 3656 |
[PDF][PDF] Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses
The SARS-CoV-2 proteome shares regions of conservation with endemic human coronaviruses
(CoVs), but it remains unknown to what extent these may be cross-recognized by the …
(CoVs), but it remains unknown to what extent these may be cross-recognized by the …
[HTML][HTML] Discovery and development of safe-in-man broad-spectrum antiviral agents
Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific
vaccines and antiviral drugs are the most powerful tools to combat viral diseases. …
vaccines and antiviral drugs are the most powerful tools to combat viral diseases. …
[HTML][HTML] Potential antiviral options against SARS-CoV-2 infection
As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2)
continues to skyrocket, with more than 6.7 million cases worldwide. Both the …
continues to skyrocket, with more than 6.7 million cases worldwide. Both the …
[HTML][HTML] Influenza virus infection, interferon response, viral counter-response, and apoptosis
Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remain
serious threats to public health because of the shortage of effective means of control. To …
serious threats to public health because of the shortage of effective means of control. To …
[HTML][HTML] Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010–2018
With the increasing pace of global warming, it is important to understand the role of
meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of …
meteorological factors in influenza virus (IV) epidemics. In this study, we investigated the impact of …
Recapitulating hepatitis E virus–host interactions and facilitating antiviral drug discovery in human liver–derived organoids
…, MMA Verstegen, Y Wang, TC Li, Z Ma, DE Kainov… - Science …, 2022 - science.org
Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the development
of robust experimental models. The advent of organoid technology provides a unique …
of robust experimental models. The advent of organoid technology provides a unique …
[HTML][HTML] Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation
Many viruses package their genome into preformed capsids using packaging motors
powered by the hydrolysis of ATP. The hexameric ATPase P4 of dsRNA bacteriophage φ12, …
powered by the hydrolysis of ATP. The hexameric ATPase P4 of dsRNA bacteriophage φ12, …
[HTML][HTML] Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19
Therapeutic options for coronaviruses remain limited. To address this unmet medical need,
we screened 5406 compounds, including United States Food and Drug Administration (FDA)-…
we screened 5406 compounds, including United States Food and Drug Administration (FDA)-…
Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism
…, V Velagapudi, JK De Brabander, DE Kainov… - Antiviral research, 2017 - Elsevier
An epidemic of Zika virus (ZIKV) infection associated with congenital abnormalities such as
microcephaly, is ongoing in the Americas and the Pacific. Currently there are no approved …
microcephaly, is ongoing in the Americas and the Pacific. Currently there are no approved …
[HTML][HTML] Novel antiviral activities of obatoclax, emetine, niclosamide, brequinar, and homoharringtonine
Viruses are the major causes of acute and chronic infectious diseases in the world. According
to the World Health Organization, there is an urgent need for better control of viral diseases…
to the World Health Organization, there is an urgent need for better control of viral diseases…