Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
…, J Xu, CJ Haddock, C Li, BJ Lee, DG Loredan… - Elife, 2016 - elifesciences.org
10.7554/eLife.14709.001 Missense mutations in ATM kinase, a master regulator of DNA
damage responses, are found in many cancers, but their impact on ATM function and …
damage responses, are found in many cancers, but their impact on ATM function and …
Single-cell analysis of CX3CR1+ cells reveals a pathogenic role for BIRC5+ myeloid proliferating cells driven by Staphylococcus aureus leukotoxins
DG Loredan, JC Devlin, KA Lacey… - The Journal of …, 2023 - journals.aai.org
Our previous studies identified a population of stem cellčlike proliferating myeloid cells within
inflamed tissues that could serve as a reservoir for tissue macrophages to adopt different …
inflamed tissues that could serve as a reservoir for tissue macrophages to adopt different …
Recruitment and Maintenance of CX3CR1+ CD4+ T Cells during Helminth Infection
DG Loredan, JC Devlin, KM Khanna - The Journal of Immunology, 2024 - journals.aai.org
Distinct subsets of T lymphocytes express CX3CR1 under inflammatory conditions, but little
is known about CX3CR1+ CD4+ T cells during type 2 inflammation in helminth infections. In …
is known about CX3CR1+ CD4+ T cells during type 2 inflammation in helminth infections. In …
[HTML][HTML] Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
…, W Jiang, BJ Lee, DG Loredan, C Li, G Bhagat… - Journal of Hematology & …, 2015 - Springer
Bcl11b is a transcription factor important for T cell development and also a tumor-suppressor
gene that is hemizygously inactivated in ~10 % human T cell acute lymphoblastic leukemia (…
gene that is hemizygously inactivated in ~10 % human T cell acute lymphoblastic leukemia (…
A role for BCL6 in maintaining CX3CR1+ CD4+ T cells during helminth infection
Distinct subsets of T lymphocytes express CX3CR1 under inflammatory conditions, but little
is known about CX3CR1+ CD4+ T cells during Type 2 inflammation in helminth infections. …
is known about CX3CR1+ CD4+ T cells during Type 2 inflammation in helminth infections. …
[HTML][HTML] New diagnosis of atypical ataxia-telangiectasia in a 17-year-old boy with T-cell acute lymphoblastic leukemia and a novel ATM mutation
J Roohi, J Crowe, D Loredan… - Journal of human …, 2017 - nature.com
Ataxia-telangiectasia (AT) is an autosomal recessive chromosome breakage disorder caused
by mutations in the ATM gene. Typically, it presents in early childhood with progressive …
by mutations in the ATM gene. Typically, it presents in early childhood with progressive …
Extending in vitro digestion models to specific human populations: Perspectives, practical tools and bio-relevant information
…, A Brodkorb, A Cilla, A Deglaire, S Denis… - Trends in Food Science …, 2017 - Elsevier
Background In vitro digestion models show great promise in facilitating the rationale design
of foods. This paper provides a look into the current state of the art and outlines possible …
of foods. This paper provides a look into the current state of the art and outlines possible …
[PDF][PDF] Severe hematopoietic stem cell inflammation compromises chronic granulomatous disease gene therapy
…, M Semeraro, L Martignetti, A Cortal, A Denis… - Cell Reports …, 2023 - cell.com
X-linked chronic granulomatous disease (CGD) is associated with defective phagocytosis,
life-threatening infections, and inflammatory complications. We performed a clinical trial of …
life-threatening infections, and inflammatory complications. We performed a clinical trial of …
[CITATION][C] Verbale n. 11 Allegato
DER Loredana, R DREOS, C DRI, D SCAINI, G SCIAN…
[CITATION][C] ASPECTS REGARDING FLOOD OCCURRENCE. CASE STUDY: HALCENI RESERVOIR ON THE MILETIN RIVER, ROMANIA
…, B Daniel, C Flaviana, C Oana, B Ioan, CM Loredana