A major challenge in transplantation medicine is controlling the very strong immune responses
to foreign antigens that are responsible for graft rejection. Although immunosuppressive …

Several reports have documented that lymphocytes can extract surface molecules through
the'immunological synapse'from the antigen-presenting cells to which they are conjugated 1. …

Upon encounter of a CTL with a target cell carrying foreign Ags, the TCR internalizes with its
ligand, the peptide-MHC class I complex. However, it is unclear how this can happen …

Thymus-derived regulatory T lymphocytes of CD4 + CD25 + phenotype regulate a large
variety of beneficial and deleterious immune responses and can inhibit lethal graft-versus-host …

Occasional EBV infection of human NK cells may lead to malignant diseases such as naso-pharyngeal
NK lymphoma although NK cells do not express CD21, the primary receptor for …

Tuberculosis (TB), caused by the airborne bacterial pathogen Mycobacterium tuberculosis,
remains a major source of morbidity and mortality worldwide. So far, the study of host-…

T cell tolerance to self Ags is in part established in the thymus by induction of apoptosis or
anergy of potentially autoreactive thymocytes. Some autospecific T cells nevertheless migrate …

Key events of T and B cell biology are regulated through direct interaction with APC or target
cells. Trogocytosis is a process whereby CD4+ T, CD8+ T, and B cells capture their specific …

Upon recognition of their respective cellular partners, T and B cells acquire their antigens by
a process of membrane capture called trogocytosis. Here, we report that various inhibitors …

Rationale: In addition to their well-known function as antibody-producing cells, B lymphocytes
can markedly influence the course of infectious or noninfectious diseases via antibody-…