The nucleolus is the most prominent nuclear body and serves a fundamentally important
biological role as a site of ribonucleoprotein particle assembly, primarily dedicated to ribosome …

rRNAs are extensively modified during their transcription and subsequent maturation in the
nucleolus, nucleus and cytoplasm. RNA modifications, which are installed either by snoRNA-…

A system for naming ribosomal proteins is described that the authors intend to use in the
future. They urge others to adopt it. The objective is to eliminate the confusion caused by the …

Focal amplifications of chromosome 3p13–3p14 occur in about 10% of melanomas and are
associated with a poor prognosis. The melanoma-specific oncogene MITF resides at the …

Mature ribosomal RNAs (rRNAs) are produced from polycistronic precursors following
complex processing. Precursor (pre)-rRNA processing has been extensively characterized in …

Many or all of the sites of pseudouridine (Ψ) formation in eukaryotic rRNA are selected by
site-specific base-pairing with members of the box H + ACA class of small nucleolar RNAs (…

The nucleolus is the ribosome factory of the cells. This is the nuclear domain where ribosomal
RNAs are synthesized, processed, and assembled with ribosomal proteins. Here we …

Structural analyses of the large and small ribosomal subunits have allowed us to think about
how they work in more detail than ever before. The mechanisms that underlie ribosomal …

10.7554/eLife.13722.001 Antigen Ki-67 is a nuclear protein expressed in proliferating
mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, …

In eukaryotes, ribosome synthesis largely takes place in a specialized nuclear domain – the
nucleolus. It has recently become apparent that this organelle is involved in the biogenesis …