[HTML][HTML] Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
JP Coppé, CK Patil, F Rodier, YU Sun, DP Muñoz… - PLoS …, 2008 - journals.plos.org
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently,
in response to oncogenic stimuli, including genotoxic stress. We modified the use of …
in response to oncogenic stimuli, including genotoxic stress. We modified the use of …
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
…, JP Coppé, CK Patil, WAM Hoeijmakers, DP Muñoz… - Nature cell …, 2009 - nature.com
Cellular senescence suppresses cancer by stably arresting the proliferation of damaged cells
1 . Paradoxically, senescent cells also secrete factors that alter tissue microenvironments 2 …
1 . Paradoxically, senescent cells also secrete factors that alter tissue microenvironments 2 …
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
F Rodier, DP Muñoz, R Teachenor… - Journal of cell …, 2011 - journals.biologists.com
DNA damage can induce a tumor suppressive response termed cellular senescence.
Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and other …
Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and other …
Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells
…, F Urbinati, SJ Heo, T Mitros, DP Muñoz… - Science translational …, 2016 - science.org
Genetic diseases of blood cells are prime candidates for treatment through ex vivo gene
editing of CD34 + hematopoietic stem/progenitor cells (HSPCs), and a variety of technologies …
editing of CD34 + hematopoietic stem/progenitor cells (HSPCs), and a variety of technologies …
A protein interaction landscape of breast cancer
…, TK Foo, D Mitchell, KA Herrington, DP Muñoz… - Science, 2021 - science.org
INTRODUCTION Advances in DNA sequencing technology have enabled the widespread
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …
analysis of breast tumor genomes, creating a catalog of genetic mutations that may initiate or …
[HTML][HTML] A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors
…, B Pan, CA Dreyer, D Brunen, A Prahallad, DP Muñoz… - Nature cancer, 2023 - nature.com
BRAF V600E mutation confers a poor prognosis in metastatic colorectal cancer (CRC) despite
combinatorial targeted therapies based on the latest understanding of signaling circuitry. …
combinatorial targeted therapies based on the latest understanding of signaling circuitry. …
[HTML][HTML] Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging
DP Muñoz, SM Yannone, A Daemen, Y Sun… - JCI insight, 2019 - ncbi.nlm.nih.gov
Cellular senescence is a tumor-suppressive mechanism that can paradoxically contribute to
aging pathologies. Despite evidence of immune clearance in mouse models, it is not known …
aging pathologies. Despite evidence of immune clearance in mouse models, it is not known …
[HTML][HTML] Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies
…, R Carrasco, YC Hwang, DP Muñoz… - The Journal of …, 2023 - Am Soc Clin Investig
The B cell leukemia/lymphoma 2 (BCL-2) inhibitor venetoclax is effective in chronic
lymphocytic leukemia (CLL); however, resistance may develop over time. Other lymphoid …
lymphocytic leukemia (CLL); however, resistance may develop over time. Other lymphoid …
Activation-induced cytidine deaminase (AID) is necessary for the epithelial–mesenchymal transition in mammary epithelial cells
DP Muñoz, EL Lee, S Takayama… - Proceedings of the …, 2013 - National Acad Sciences
Activation-induced cytidine deaminase (AID), which functions in antibody diversification, is
also expressed in a variety of germ and somatic cells. Evidence that AID promotes DNA …
also expressed in a variety of germ and somatic cells. Evidence that AID promotes DNA …
[HTML][HTML] Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome
P Zhao, GB Tassew, JY Lee, B Oskouian, DP Muñoz… - JCI insight, 2021 - ncbi.nlm.nih.gov
Sphingosine-1-phosphate lyase insufficiency syndrome (SPLIS) is a rare metabolic disorder
caused by inactivating mutations in sphingosine-1-phosphate lyase 1 (SGPL1), which is …
caused by inactivating mutations in sphingosine-1-phosphate lyase 1 (SGPL1), which is …