A major cause of the cerebral cortex expansion that occurred during evolution is the increase
in subventricular zone (SVZ) progenitors. We found that progenitors in the outer SVZ (OSVZ…

Subventricular zone (SVZ) progenitors are a hallmark of the developing neocortex. Recent
studies described a novel type of SVZ progenitor that retains a basal process at mitosis, …

During vascular development, endothelial platelet-derived growth factor B (PDGF-B) is
critical for pericyte recruitment. Deletion of the conserved C-terminal heparin-binding motif …

How individual components of the vascular basement membrane influence endothelial cell
behaviour remains unclear. Here we show that laminin α4 (Lama4) regulates tip cell …

Fibronectin (FN) is a major component of the extracellular matrix and functions in cell
adhesion, cell spreading and cell migration. In the retina, FN is transiently expressed and …

Neocortex expansion during evolution is associated with the enlargement of the embryonic
subventricular zone, which reflects an increased self-renewal and proliferation of basal …

The importance of thyroid hormones during brain development has been appreciated for
many decades. In humans, low levels of circulating maternal thyroid hormones, eg, caused by …

Neocortex expansion is largely based on the proliferative capacity of basal progenitors (BPs),
which is increased by extracellular matrix (ECM) components via integrin signaling. Here …

Blood vessel maturation and stability require recruitment of mural cells (MCs) to the nascent
vessel. Loss or detachment of MCs causes vascular dysfunction in diseases. N-sulfation of …

The formation of mature blood vessels requires recruitment of mural cells (MC) and generation
of an extracellular matrix in order to stabilize and support the nascent vessel. The precise …