Background Clinical prognostic groupings for localised prostate cancers are imprecise, with
30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We …

Background We introduce BPG, a framework for generating publication-quality, highly-customizable
plots in the R statistical environment. Results This open-source package includes …

Objective Large clinical databases are increasingly used for research and quality
improvement. We describe an approach to data quality assessment from the General Medicine …

Background The diagnosis of Cystic Fibrosis (CF) is by consensus based on the same
parameters in all patients, yet the influence of ethnicity has only scarcely been studied. We aimed …

Numerous recent studies have suggested that phenotypic effects of DNA sequence variants
can be mediated or modulated by their epigenetic marks, such as allele-skewed DNA …

Motivation: Standard search techniques for DNA repeats start by identifying small matching
words, or seeds, that may inhabit larger repeats. Recent innovations in seed structure …

Background Quantitative real-time PCR (qPCR) is the “gold-standard” technique for measuring
mRNA abundances. To correctly compare samples and generate biologically valid results…

Let a seed, S, be a string from the alphabet {1,*}, of arbitrary length k, which starts and ends
with a 1. For example, S = 11*1. S occurs in a binary string T at position h if the length k …

The chest x-ray is a commonly requested diagnostic test on internal medicine wards which
can diagnose many acute pathologies needing intervention. We developed a natural …

The accurate computational prediction of RNA secondary structures is a difficult task, but an
important one, since RNA structure is usually more evolutionarily conserved than primary …