User profiles for Deniz Saltukoglu

Deniz Saltukoglu

Postdoctoral researcher
Verified email at bioss.uni-freiburg.de
Cited by 1841

U-Net: deep learning for cell counting, detection, and morphometry

…, O Tietz, C Dal Bosco, S Walsh, D Saltukoglu… - Nature …, 2019 - nature.com
U-Net is a generic deep-learning solution for frequently occurring quantification tasks such
as cell detection and shape measurements in biomedical image data. We present an ImageJ …

[PDF][PDF] Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit

T Hermle, D Saltukoglu, J Grünewald, G Walz… - Current Biology, 2010 - cell.com
Frizzled (Fz) is a seven-pass transmembrane receptor that acts in both Wingless (Wg) and
planar cell polarity (PCP) pathways. A prerequisite for PCP signaling is the asymmetric …

Structural principles of B cell antigen receptor assembly

Y Dong, X Pi, F Bartels-Burgahn, D Saltukoglu, Z Liang… - Nature, 2022 - nature.com
The B cell antigen receptor (BCR) is composed of a membrane-bound class M, D, G, E or A
immunoglobulin for antigen recognition 1 , 2 – 3 and a disulfide-linked Igα (also known as …

Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters

D Saltukoglu, B Özdemir, M Holtmannspötter… - The EMBO …, 2023 - embopress.org
B lymphocytes recognize bacterial or viral antigens via different classes of the B cell antigen
receptor (BCR). Protrusive structures termed microvilli cover lymphocyte surfaces, and are …

Author Correction: U-Net: deep learning for cell counting, detection, and morphometry

…, O Tietz, CD Bosco, S Walsh, D Saltukoglu… - Nature …, 2019 - nature.com
The version of this paper originally published cited a preprint version of ref. 12 instead of the
published version (Proc. Natl. Acad. Sci. USA 115, 5594–5599; 2018), which was available …

Spontaneous and electric field–controlled front–rear polarization of human keratinocytes

D Saltukoglu, J Grünewald, N Strohmeyer… - Molecular Biology of …, 2015 - Am Soc Cell Biol
It has long been known that electrical fields (EFs) are able to influence the direction of migrating
cells, a process commonly referred to as electrotaxis or galvanotaxis. Most studies have …

Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes

…, L Hoenig, X He, D Saltukoglu… - Life Science …, 2020 - life-science-alliance.org
The major function of B lymphocytes is to sense antigens and to produce protective antibodies
after activation. This function requires the expression of a B-cell antigen receptor (BCR), …

Plasma membrane topography governs the three-dimensional dynamic localization of IgM B cell receptor clusters

D Saltukoglu, B Özdemir, M Holtmannspötter, R Reski… - bioRxiv, 2022 - biorxiv.org
B lymphocytes recognize bacterial or viral antigens via different classes of the B cell antigen
receptor (BCR). Protrusive structures termed microvilli cover lymphocyte surfaces and are …

Engineered chimeric T cell receptor fusion construct (TRuC)-expressing T cells prevent translational shutdown in SARS-CoV-2-infected cells

…, OS Yousefi, S Pathan-Chhatbar, D Saltukoglu… - bioRxiv, 2021 - biorxiv.org
SARS-CoV-2, the causative agent of Covid-19, is known to evade the immune system by
several mechanisms. This includes the shutdown of the host cellular protein synthesis, which …

A distributed stochastic perception-action loop model of cell motility

M Buck, D Saltukoglu, M Boerries… - … IEEE Symposium on …, 2013 - ieeexplore.ieee.org
In this paper, we present a novel framework for the modeling of cell-migration, and more
specifically the migration of human keratinocytes. The model decouples the embodiment of an …