Normal tissue cells are generally not viable when suspended in a fluid and are therefore said
to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as rigid …

Microenvironments appear important in stem cell lineage specification but can be difficult to
adequately characterize or control with soft tissues. Naive mesenchymal stem cells (MSCs) …

Synthetic carriers such as polymer and lipid particles often struggle to meet clinical expectations.
Natural particulates — that range from pathogens to mammalian cells — are therefore …

Stem cell fate is influenced by a number of factors and interactions that require robust
control for safe and effective regeneration of functional tissue. Coordinated interactions with …

Vesicles are microscopic sacs that enclose a volume with a molecularly thin membrane. The
membranes are generally self-directed assemblies of amphiphilic molecules with a dual …

Interaction of spherical particles with cells and within animals has been studied extensively,
but the effects of shape have received little attention. Here we use highly stable, polymer …

Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little mechanical
stress, or stiff like muscle, cartilage, and bone, which sustain high levels of stress. …

Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation.
The average molecular weight of the specific polymer studied, polyethyleneoxide-…

… Lee Sweeney, Dennis E. Discher; Myotubes differentiate optimally on substrates with
tissue-like stiffness : pathological implications for soft or stiff microenvironments . J Cell Biol 13 …

To identify cytoskeletal proteins that change conformation or assembly within stressed cells,
in situ labeling of sterically shielded cysteines with fluorophores was analyzed by …