Genome-wide association studies (GWAS) have identified 76 variants associated with
prostate cancer risk predominantly in populations of European ancestry. To identify additional …

Background: Common cancers develop through a multistep process often including inherited
susceptibility. Collaboration among multiple institutions, and funding from multiple sources, …

Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs)
produce monocytes during homeostasis and in response to increased demand during …

Functional annotation represents a key step toward the understanding and interpretation of
germline and somatic variation as revealed by genome-wide association studies (GWAS) …

Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics,
but the causal links between increased genetic risk and onset/progression of disease …

Signaling by the secreted hedgehog, decapentaplegic and wingless proteins organizes the
pattern of photoreceptor differentiation within the Drosophila eye imaginal disc; hedgehog …

Abstract Treatment of prostate cancer (PC) by androgen suppression promotes the emergence
of aggressive variants that are androgen receptor (AR) independent. Here we identify the …

Genome-wide association studies (GWAS) have identified numerous common prostate
cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the …

The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate
cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8–128.8Mb) in …

Motivation DNA methylation has been used to identify functional changes at transcriptional
enhancers and other cis-regulatory modules (CRMs) in tumors and other disease tissues. …