Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable
biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting ligands. …

Telomeres are actively transcribed into telomeric repeat-containing RNA (TERRA), which has
been implicated in the regulation of telomere length and heterochromatin formation. Here, …

Telomeres are bound by dedicated proteins, which protect them from DNA damage and
regulate telomere length homeostasis. In the nematode Caenorhabditis elegans, a …

Three ionotropic glutamate receptor subunits, designated GluRIIA, GluRIIB, and GluRIII, have
been identified at neuromuscular junctions of Drosophila. Whereas GluRIIA and GluRIIB …

PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the
most important mechanisms in mitochondrial quality control (MQC) via the clearance of …

Telomere shortening accompanies human aging, and premature aging syndromes are often
associated with short telomeres. These two observations are central to the hypothesis that …

Drosophila melanogaster is a widely used genetic model organism in developmental
biology. While this model organism has been intensively studied at the RNA level, a …

Competitive BET bromodomain inhibitors (BBIs) targeting BET proteins (BRD2, BRD3, BRD4,
and BRDT) show promising preclinical activities against brain cancers. However, the BET …

Background Deregulated gene expression is a hallmark of cancer; however, most studies to
date have analyzed short-read RNA sequencing data with inherent limitations. Here, we …