We investigate the logic by which sensory input is translated into behavioral output. First we
provide a functional analysis of the entire odor receptor repertoire of an olfactory system. We …

Bone is a natural composite material consisting of an organic phase (collagen) and a mineral
phase (calcium phosphate, especially hydroxyapatite). The strength of bone is attributed to …

Wingless secretion provides pivotal signals during development by activating transcription of
target genes. At Drosophila synapses, Wingless is secreted from presynaptic terminals and …

Small animals such as nematodes and insects analyze airborne chemical cues to infer the
direction of favorable and noxious locations. In these animals, the study of navigational …

The ability of an animal to detect, discriminate, and respond to odors depends on the function
of its olfactory receptor neurons (ORNs), which in turn depends ultimately on odorant …

Background: Membrane-associated guanylate kinases (MAGUKs), such as Discs-Large (DLG),
play critical roles in synapse maturation by regulating the assembly of synaptic …

A promising strategy for augmenting bone formation involves the local delivery of multiple
osteoinductive and vasculogenic growth factors. However, success depends on sustained …

The Wingless pathway plays an essential role during synapse development. Recent studies
at Drosophila glutamatergic synapses suggest that Wingless is secreted by motor neuron …

The formation of mature synaptic connections involves the targeted transport and aggregation
of synaptic vesicles, the gathering of presynaptic release sites and the clustering of …

Starvation enhances olfactory sensitivity that encourage animals to search for food. The
molecular mechanisms that enable sensory neurons to remain flexible and adapt to a particular …