Upon intravenous administration of nanoparticles (NP) into the bloodstream, proteins bind
rapidly on their surface resulting in a formation of a so-called ‘Protein Corona’. These proteins …

Background: When nanoparticles (NPs) are applied into a biological fluid, such as blood,
proteins bind rapidly to their surface forming a so-called “protein corona”. These proteins are …

T-2 toxin belongs to the large group of trichothecene mycotoxins synthesized by various
Fusarium molds which can infect raw agriculture materials. Among the trichothecenes, T-2 toxin …

Shiga toxin (Stx)-mediated injury to vascular endothelial cells in the kidneys, brain and
other organs underlies the pathogenesis of haemolytic uraemic syndrome (HUS) caused by …

Ergot alkaloids are secondary metabolites produced by fungi of the species Claviceps. Toxic
effects after consumption of contaminated grains are described since mediaeval times. Of …

The physico-chemical characterisation of nanoparticles is often lacking the determination of
the glass transition temperature, a well-known parameter for the pure polymer carrier. In the …

Nanoparticles based on biodegradable polymers are well-known as approved carrier
systems for a diversity of drugs. Despite their advantages, such as the option of an active drug …

Aliphatic poly(carbonate)s (APCs) with rapid and controlled degradation upon specific
stimulation have great advantages for a variety of biomedical and pharmaceutical applications. In …

Over the last few decades the establishment of nanoparticles as suitable drug carriers with
the transport of drugs across biological barriers such as the gastrointestinal barrier moved …

Resistance to systemic drug therapy is a major reason for the failure of anticancer therapies.
Here, we tested doxorubicin-loaded human serum albumin (HSA) nanoparticles in the …