Selecting particles from digital micrographs is an essential step in single-particle electron
cryomicroscopy (cryo-EM). As manual selection of complete datasets—typically comprising …

Type VI secretion (T6S) influences the composition of microbial communities by catalyzing
the delivery of toxins between adjacent bacterial cells. Here, we demonstrate that a T6S …

The type VI secretion system (T6SS) primarily functions to mediate antagonistic interactions
between contacting bacterial cells, but also mediates interactions with eukaryotic hosts. This …

Canonical transient receptor potential channels (TRPC) are involved in receptor-operated
and/or store-operated Ca 2+ signaling. Inhibition of TRPCs by small molecules was shown to …

The pentameric FERRY Rab5 effector complex is a molecular link between mRNA and early
endosomes in mRNA intracellular distribution. Here, we determine the cryo-EM structure of …

The type VI secretion system (T6SS) is a widespread protein export apparatus found in
Gram-negative bacteria. The majority of T6SSs deliver toxic effector proteins into competitor …

A human cell is a precisely regulated system that relies on the complex interaction of molecules.
Structural insights into the cellular machinery at the atomic level allow us to understand …

Type VI secretion systems (T6SSs) deliver antibacterial effector proteins between neighboring
bacteria. Many effectors harbor N-terminal transmembrane domains (TMDs) implicated in …

Anthrax toxin is the major virulence factor secreted by Bacillus anthracis, causing high
mortality in humans and other mammals. It consists of a membrane translocase, known as …

Long-range mRNA transport is crucial for the spatio-temporal regulation of gene expression,
and its malfunction leads to neurological disorders. The pentameric FERRY Rab5 effector …