To understand the pathogenesis of chronic inflammatory disease, we analyzed an
experimental mouse model of chronic lung disease with pathology that resembles asthma and …

Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial and
immune cell function that are driven, at least in part, by infection. Analysis of parainfluenza …

An abnormal immune response to environmental agents is generally thought to be
responsible for causing chronic respiratory diseases, such as asthma and chronic obstructive …

Increased mucus production is a common cause of morbidity and mortality in inflammatory
airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and …

Viral infections and type 2 immune responses are thought to be critical for the development
of chronic respiratory disease, but the link between these events needs to be better defined. …

Background Antibody-mediated rejection (AMR) after lung transplantation remains enigmatic,
and there is no consensus on the characteristic clinical, immunologic and histologic …

Macrophages are the most abundant immune cell population in normal lung tissue and
serve critical roles in innate and adaptive immune responses as well as the development of …

BACKGROUND Lung transplant (LTx) recipients have low long-term survival and a high
incidence of bronchiolitis obliterans syndrome (BOS). However, few long-term, multicenter, and …

The impact of lipotoxicity on the development of lung fibrosis is unclear. Saturated fatty acids,
such as palmitic acid (PA), activate endoplasmic reticulum (ER) stress, a cellular stress …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease
without effective molecular markers of disease activity or treatment responses. Monocyte and …