Using microarray-based profiling of isogenic prostate cancer xenograft models, we found
that a modest increase in androgen receptor mRNA was the only change consistently …

Inhibitors of the kinase mammalian target of rapamycin (mTOR) have shown sporadic activity
in cancer trials, leading to confusion about the appropriate clinical setting for their use. …

Glaucoma, a major cause of blindness worldwide, is a neurodegenerative optic neuropathy
in which vision loss is caused by loss of retinal ganglion cells (RGCs). To better define the …

INTRODUCTION Cone photoreceptors in the human retina enable daytime, color, and high-acuity
vision. The three subtypes of human cones are defined by the visual pigment that they …

Transcriptional activity of the androgen receptor (AR) is crucial for growth and survival of
prostate cancer even upon development of resistance to androgen ablation and antiandrogen …

One of the earliest steps in the development of the atherosclerotic lesion is the accumulation
of monocyte/macrophages within the vessel wall. Oxidized lipids present in minimally …

Vision loss from ischemic retinopathies commonly results from the accumulation of fluid in
the inner retina [macular edema (ME)]. Although the precise events that lead to the …

Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to
axonal damage in retinal ganglion cells (RGCs) and other neurons. To better understand the …

Human pluripotent stem cells have the potential to promote biological studies and accelerate
drug discovery efforts by making possible direct experimentation on a variety of human cell …

Delayed revascularization of ischemic neural tissue is a major impediment to preservation
of function in central nervous system (CNS) diseases including stroke and ischemic …