User profiles for Derek Shyr
 | Derek ShyrHarvard University Verified email at mail.harvard.edu Cited by 353 |
[HTML][HTML] Next generation sequencing in cancer research and clinical application
The wide application of next-generation sequencing (NGS), mainly through whole genome,
exome and transcriptome sequencing, provides a high-resolution and global view of the …
exome and transcriptome sequencing, provides a high-resolution and global view of the …
[HTML][HTML] Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations
Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic
relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an …
relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an …
Comprehensive evaluation of context dependence of the prognostic impact of MYCN amplification in neuroblastoma: A report from the International Neuroblastoma …
K Campbell, D Shyr, R Bagatell, M Fischer… - Pediatric blood & …, 2019 - Wiley Online Library
Background MYCN amplification (MYCN‐A) is an established adverse prognostic factor in
neuroblastoma. The extent to which the prognostic impact of MYCN‐A depends on other …
neuroblastoma. The extent to which the prognostic impact of MYCN‐A depends on other …
[HTML][HTML] Unraveling attributes of COVID-19 vaccine acceptance and uptake in the US: A large nationwide study
SARS-CoV-2 vaccines are useful tools to combat the Coronavirus Disease 2019 (COVID-19)
pandemic, but vaccine reluctance threatens these vaccines’ effectiveness. To address …
pandemic, but vaccine reluctance threatens these vaccines’ effectiveness. To address …
Unraveling attributes of COVID-19 vaccine hesitancy and uptake in the US: A large nationwide study
SARS-CoV-2 vaccines are powerful tools to combat the COVID-19 pandemic, but vaccine
hesitancy threatens these vaccines’ effectiveness. To address COVID-19 vaccine hesitancy …
hesitancy threatens these vaccines’ effectiveness. To address COVID-19 vaccine hesitancy …
Feasibility of systematic poverty screening in a pediatric oncology referral center
Background Based on the strong link between poverty and child health outcomes, both the
American Academy of Pediatrics (AAP) and national pediatric oncology associations have …
American Academy of Pediatrics (AAP) and national pediatric oncology associations have …
[PDF][PDF] Sample size calculation of RNA-sequencing experiment: a simulation-based approach of TCGA data
D Shyr, CI Li - J Biomet Biostat, 2014 - pdfs.semanticscholar.org
Power and sample size calculation is an essential component of experimental design in
biomedical research. For RNA-sequencing experiments, sample size calculations have been …
biomedical research. For RNA-sequencing experiments, sample size calculations have been …
Multicenter Phase II Trial of the PARP Inhibitor Olaparib in Recurrent IDH1- and IDH2-mutant Glioma
Purpose: Isocitrate dehydrogenase (IDH) 1 and IDH2 mutations (IDH1/2mt) are frequent in
glioma. Preclinical studies suggest IDH1/2mts confer “BRCAness” phenotype, a vulnerability …
glioma. Preclinical studies suggest IDH1/2mts confer “BRCAness” phenotype, a vulnerability …
What constitutes a valid surrogate end point in cancer clinical trials?
Historically, novel postneoadjuvant therapies for patients with early breast cancer have
been assessed in multiyear trials. In an effort to address the unmet need of postneoadjuvant …
been assessed in multiyear trials. In an effort to address the unmet need of postneoadjuvant …
[HTML][HTML] Decoding biological age from face photographs using deep learning
Because humans age at different rates, a person’s physical appearance may yield insights
into their biological age and physiological health more reliably than their chronological age. …
into their biological age and physiological health more reliably than their chronological age. …