Therapeutic messenger RNA vaccines enable delivery of whole antigens, which can be
advantageous over peptide vaccines. However, optimal efficacy requires both intracellular …

Lipid-like nanoparticles (LNPs) have potential as non-viral delivery systems for mRNA
therapies. However, repeated administrations of LNPs may lead to accumulation of delivery …

Antibody-based drugs are a leading class of biologics used to treat a variety of diseases,
including cancer. However, wide antibody implementation is hindered by manufacturing …

Bioactive nanoscale arrays were constructed to ligate activating cell surface receptors on T
cells (the CD3 component of the TCR complex) and natural killer (NK) cells (CD16). These …

Recent advances in biomaterials design offer the potential to actively control immune cell
activation and behaviour. Many human diseases, such as infections, cancer, and autoimmune …

To mimic native insulin activity, materials have been developed that encapsulate insulin,
glucose oxidase, and catalase for glucose-responsive insulin delivery. A major challenge, …

Encapsulated beta cell transplantation offers a potential cure for a subset of diabetic patients.
Once transplanted, beta cell grafts can help to restore glycemic control; however, locating …

Over the last century, there has been a dramatic change in the nature of therapeutic,
biologically active molecules available to treat disease. Therapies have evolved from extracted …

Polymer microparticles are widely used as acellular drug delivery platforms in regenerative
medicine, and have emerging potential as cellular scaffolds for therapeutic cell delivery. In …

Islet transplantation is a promising therapy for a subset of people with Type 1 diabetes (T1D).
However, beta cell transplant clinical trials have largely failed to maintain long-term normal …