Lipins are phosphatidate phosphatases that generate diacylglycerol (DAG). In this study, we
report that yeast lipin, Pah1p, controls the formation of cytosolic lipid droplets. Disruption of …

Seipin is necessary for both adipogenesis and lipid droplet (LD) organization in nonadipose
tissues; however, its molecular function is incompletely understood. Phenotypes in the …

Abundant evidence has shown that the GTPase dynamin is required for receptor-mediated
endocytosis, but its exact role in endocytic clathrin-coated vesicle formation remains to be …

The primary structure of PI31, a protein inhibitor of the 20 S proteasome, was deduced by
cDNA cloning and sequencing. The human protein has a calculated molecular weight of …

Phosphatidylinositolpolyphosphates (PIPs) are centrally involved in many biological
processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and …

Pet10p is a yeast lipid droplet protein of unknown function. We show that it binds specifically
to and is stabilized by droplets containing triacylglycerol (TG). Droplets isolated from cells …

Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase (NMNAT) is an
indispensable enzyme in the biosynthesis of NAD + and NADP + . Human NMNAT displays …

Phosphatidylinositol 4-kinases play essential roles in cell signaling and membrane trafficking.
They are divided into type II and III families, which have distinct structural and enzymatic …

Background Seipin is required for the correct assembly of cytoplasmic lipid droplets. In the
absence of the yeast seipin homolog Sei1p (formerly Fld1p), droplets are slow to bud from the …

Activity-regulated cytoskeletal-associated protein (Arc, also known as activity-regulated gene
3.1 or Arg3.1) is induced in neurons in response to salient experience and neural activity …