CD4 + T cells are central mediators of autoimmune pathology; however, defining their key
effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4 + T …

Many exogenous sources of stress can lead to cell death. In recent years, endogenous
cellular sources of stress have also been identified, including the stress that arises from the …

The unfolded protein response (UPR) is a stress response pathway that is driven by the
increased load of unfolded proteins in the endoplasmic reticulum of highly secretory cells such …

Objective Nephrogenic systemic fibrosis (NSF) is a rapidly progressive, debilitating condition
that causes cutaneous and visceral fibrosis in patients with renal failure. Little is known …

Drugâ•’Associated Polymyalgia Rheumatica/Giant Cell Arteritis Occurring in Two Patients
After Treatment With Ipilimumab, an Page 1 ARTHRITIS & RHEUMATOLOGY Vol. 66, No. 3, …

Importance Ipilimumab, a human monoclonal antibody targeted against cytotoxic T-lymphocyte
antigen 4, has shown promise in the treatment of metastatic melanoma. However, given …

High-dimensional single-cell analyses have improved the ability to resolve complex mixtures
of cells from human disease samples; however, identifying disease-associated cell types or …

Objective Racial/ethnic minorities experience more severe outcomes of coronavirus disease
2019 (COVID‐19) in the general US population. This study was undertaken to examine the …

Background Some patients with systemic autoimmune rheumatic disease and
immunosuppression might still be at risk of severe COVID-19. The effect of outpatient SARS-CoV-2 …

Gadolinium-based contrast agents (GBCAs), once believed to be safe for patients with renal
disease, have been strongly associated with nephrogenic systemic fibrosis (NSF), a severe …