Pseudomonas aeruginosa and Escherichia coli are resistant to wide range of antibiotics
rendering the treatment of infections very difficult. A main mechanism attributed to the resistance …

Introduction: Structure-based drug design is a wide area of identification of selective inhibitors
of a target of interest. From the time of the availability of three dimensional structure of the …

Identifying the interactions between drugs and target proteins is a key step in drug discovery.
This not only aids to understand the disease mechanism, but also helps to identify …

World Health Organization declared coronavirus disease (COVID-19) caused by SARS
coronavirus-2 (SARS-CoV-2) as pandemic. Its outbreak started in China in Dec 2019 and rapidly …

A series of homoleptic bis(terpyridine)copper(II) complexes of the type [Cu(L1–5)2]Cl2 (1–5),
where L1–5 = 4′-(4-substituted)-2,2′:6′,2′′-terpyridines, have been synthesized and …

Snake venoms are mixtures of biologically-active proteins and peptides, and several studies
have described the characteristics of some of these toxins. However, complete proteomic …

BACKGROUND: The present study focuses on identifying and developing an anti-diabetic
molecule from plant sources that would effectively combat insulin resistance through proper …

Motivation: Distinguishing between amyloid fibril-forming and amorphous β-aggregating
aggregation-prone regions (APRs) in proteins and peptides is crucial for designing novel …

Elevated production of arachidonic acid (AA)-derived pro-inflammatory eicosanoids due to
the concerted action of secretory phospholipase A 2 group IIA (sPLA 2 IIA), 5-lipoxygenase (5-…

4-[(1Z)-1-(2-carbamothioylhydrazinylidene)ethyl]phenyl acetate [Ace semi],4-[(1Z)-1-(2-carbamothioylhydrazinylidene)ethyl]phenyl
propanoate [Pro semi] from the family of …