Microcomputed tomography (microCT) has become a standard and essential tool for quantifying
structure-function relationships, disease progression, and regeneration in preclinical …

The functions of the paralogous transcriptional coactivators Yes-associated protein (YAP)
and transcriptional coactivator with PDZ-binding motif (TAZ) in bone are controversial. Each …

Large bone defects cannot form a callus and exhibit high complication rates even with the
best treatment strategies available. Tissue engineering approaches often use scaffolds …

Cell migration initiates by traction generation through reciprocal actomyosin tension and focal
adhesion reinforcement, but continued motility requires adaptive cytoskeletal remodeling …

Spatial segregation of mRNAs in the cytoplasm of cells is a well‐known biological
phenomenon that is widely observed in diverse species spanning different kingdoms of life. In …

Insufficient blood vessel supply is a primary limiting factor for regenerative approaches to
large bone defect repair. Recombinant bone morphogenetic protein-2 (BMP-2) delivery …

Bone is one of the most common and most dangerous sites for metastatic growth across
cancer types, and bone metastasis remains incurable. Unfortunately, the processes by which …

Bone is a dynamic tissue that can adapt its architecture in response to mechanical signals
under the control of osteocytes, which sense mechanical deformation of the mineralized bone. …

Super-resolution fluorescence microscopy is an important tool in biomedical research for its
ability to discern features smaller than the diffraction limit. However, due to its difficult …

A common design constraint in functional tissue engineering is that scaffolds intended for
use in load-bearing sites possess similar mechanical properties to the replaced tissue. Here, …