User profiles for Devrim Pesen Okvur

Devrim Pesen Okvur

Molecular Biology and Genetics, Izmir Institute of Technology
Verified email at iyte.edu.tr
Cited by 1054

Cancer stem cells in tumor modeling: Challenges and future directions

…, GJ Kubicek, D Pesen-Okvur… - Advanced …, 2021 - Wiley Online Library
Microfluidic tumors‐on‐chips models have revolutionized anticancer therapeutic research
by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) …

Breast cancer cells and macrophages in a paracrine-juxtacrine loop

…, G Bati-Ayaz, H Yanik, D Pesen-Okvur - Biomaterials, 2021 - Elsevier
Breast cancer cells (BCC) and macrophages are known to interact via epidermal growth
factor (EGF) produced by macrophages and colony stimulating factor-1 (CSF-1) produced by …

A new drug testing platform based on 3D tri-culture in lab-on-a-chip devices

B Gokce, I Akcok, A Cagir, D Pesen-Okvur - European Journal of …, 2020 - Elsevier
Drug discovery has a 90% rate of failure because preclinical platforms for drug testing do
not mimic the in vivo conditions. Doxorubicin (DOX) is a commonly used drug to treat breast …

[HTML][HTML] Step-by-step quantitative analysis of focal adhesions

U Horzum, B Ozdil, D Pesen-Okvur - MethodsX, 2014 - Elsevier
Focal adhesions (FAs) are specialized adhesive structures which serve as cellular
communication units between cells and the surrounding extracellular matrix. FAs are involved in …

On‐chip determination of tissue‐specific metastatic potential of breast cancer cells

…, I Tahmaz, M Bilgen, D PesenOkvur… - Biotechnology and …, 2021 - Wiley Online Library
Metastasis is one of the major obstacles for breast cancer patients. Limitations of current models
demand the development of custom platforms to predict metastatic potential and homing …

[HTML][HTML] Fabrication of 3D Controlled in vitro Microenvironments

B Ozdil, S Onal, T Oruc, DP Okvur - MethodsX, 2014 - Elsevier
Microfluidics-based lab-on-a-chips have many advantages, one of which is to provide
physiologically relevant settings for cell biology experiments. Thus there is an ever increasing …

[HTML][HTML] FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer

…, H Uzuner, G Karakülah, D Pesen-Okvur… - Communications …, 2023 - nature.com
Bladder cancer is mostly present in the form of urothelium carcinoma, causing over 150,000
deaths each year. Its histopathological classification as muscle invasive (MIBC) and non-…

Differentiation of normal and cancer cell adhesion on custom designed protein nanopatterns

U Horzum, B Ozdil, D Pesen-Okvur - Nano letters, 2015 - ACS Publications
Cell adhesion to the extracellular matrix is deregulated in metastasis. However, traditional
surfaces used to study cell adhesion do not faithfully mimic the in vivo microenvironment. …

Cell segmentation of 2d phase-contrast microscopy images with deep learning method

…, HO Yağar, ÖY Özuysal, DP Okvur… - 2019 Medical …, 2019 - ieeexplore.ieee.org
The quantitative and qualitative ascertainment of cell culture is integral to the robust
determination of the cell structure analysis. Microscopy cell analysis and the epithet structures of …

Improved cell segmentation using deep learning in label-free optical microscopyimages

A Ayanzadeh, ÖY Özuysal, DP Okvur… - Turkish Journal of …, 2021 - journals.tubitak.gov.tr
The recently popular deep neural networks (DNNs) have a significant effect on the
improvement of segmentation accuracy from various perspectives, including robustness and …