User profiles for Devrim Pesen Okvur
Devrim Pesen OkvurMolecular Biology and Genetics, Izmir Institute of Technology Verified email at iyte.edu.tr Cited by 1054 |
Cancer stem cells in tumor modeling: Challenges and future directions
…, GJ Kubicek, D Pesen-Okvur… - Advanced …, 2021 - Wiley Online Library
Microfluidic tumors‐on‐chips models have revolutionized anticancer therapeutic research
by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) …
by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) …
Breast cancer cells and macrophages in a paracrine-juxtacrine loop
Breast cancer cells (BCC) and macrophages are known to interact via epidermal growth
factor (EGF) produced by macrophages and colony stimulating factor-1 (CSF-1) produced by …
factor (EGF) produced by macrophages and colony stimulating factor-1 (CSF-1) produced by …
A new drug testing platform based on 3D tri-culture in lab-on-a-chip devices
Drug discovery has a 90% rate of failure because preclinical platforms for drug testing do
not mimic the in vivo conditions. Doxorubicin (DOX) is a commonly used drug to treat breast …
not mimic the in vivo conditions. Doxorubicin (DOX) is a commonly used drug to treat breast …
[HTML][HTML] Step-by-step quantitative analysis of focal adhesions
Focal adhesions (FAs) are specialized adhesive structures which serve as cellular
communication units between cells and the surrounding extracellular matrix. FAs are involved in …
communication units between cells and the surrounding extracellular matrix. FAs are involved in …
On‐chip determination of tissue‐specific metastatic potential of breast cancer cells
Metastasis is one of the major obstacles for breast cancer patients. Limitations of current models
demand the development of custom platforms to predict metastatic potential and homing …
demand the development of custom platforms to predict metastatic potential and homing …
[HTML][HTML] Fabrication of 3D Controlled in vitro Microenvironments
Microfluidics-based lab-on-a-chips have many advantages, one of which is to provide
physiologically relevant settings for cell biology experiments. Thus there is an ever increasing …
physiologically relevant settings for cell biology experiments. Thus there is an ever increasing …
[HTML][HTML] FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer
…, H Uzuner, G Karakülah, D Pesen-Okvur… - Communications …, 2023 - nature.com
Bladder cancer is mostly present in the form of urothelium carcinoma, causing over 150,000
deaths each year. Its histopathological classification as muscle invasive (MIBC) and non-…
deaths each year. Its histopathological classification as muscle invasive (MIBC) and non-…
Differentiation of normal and cancer cell adhesion on custom designed protein nanopatterns
Cell adhesion to the extracellular matrix is deregulated in metastasis. However, traditional
surfaces used to study cell adhesion do not faithfully mimic the in vivo microenvironment. …
surfaces used to study cell adhesion do not faithfully mimic the in vivo microenvironment. …
Cell segmentation of 2d phase-contrast microscopy images with deep learning method
…, HO Yağar, ÖY Özuysal, DP Okvur… - 2019 Medical …, 2019 - ieeexplore.ieee.org
The quantitative and qualitative ascertainment of cell culture is integral to the robust
determination of the cell structure analysis. Microscopy cell analysis and the epithet structures of …
determination of the cell structure analysis. Microscopy cell analysis and the epithet structures of …
Improved cell segmentation using deep learning in label-free optical microscopyimages
The recently popular deep neural networks (DNNs) have a significant effect on the
improvement of segmentation accuracy from various perspectives, including robustness and …
improvement of segmentation accuracy from various perspectives, including robustness and …