In vivo characterization and quantification of neurofibrillary tau PET radioligand 18F-MK-6240 in humans from Alzheimer disease dementia to young controls
Tau PET imaging has potential for elucidating changes in the deposition of neuropathological
tau aggregates that are occurring during the progression of Alzheimer disease (AD). This …
tau aggregates that are occurring during the progression of Alzheimer disease (AD). This …
Amyloid burden and neural function in people at risk for Alzheimer's Disease
…, S Harding, G Xu, AT Hillmer, DW Wooten, D Murali… - Neurobiology of …, 2014 - Elsevier
To determine the relationship between amyloid burden and neural function in healthy adults
at risk for Alzheimer's Disease (AD), we used multimodal imaging with [C-11]Pittsburgh …
at risk for Alzheimer's Disease (AD), we used multimodal imaging with [C-11]Pittsburgh …
[HTML][HTML] Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: a multimodal imaging investigation
…, J Oh, CA Cleary, A Birdsill, AT Hillmer, D Murali… - NeuroImage: Clinical, 2014 - Elsevier
Some cognitively healthy individuals develop brain amyloid accumulation, suggestive of
incipient Alzheimer's disease (AD), but the effect of amyloid on other potentially informative …
incipient Alzheimer's disease (AD), but the effect of amyloid on other potentially informative …
The effects of normal aging on amyloid‐β deposition in nondemented adults with Down syndrome as imaged by carbon 11–labeled Pittsburgh compound B
…, R Hardison, RV Tumuluru, D Murali… - Alzheimer's & …, 2016 - Wiley Online Library
Introduction In Down syndrome (DS), the overproduction of amyloid precursor protein is
hypothesized to predispose young adults to early expression of Alzheimer‐like neuropathology. …
hypothesized to predispose young adults to early expression of Alzheimer‐like neuropathology. …
In vivo comparison of tau radioligands 18F-THK-5351 and 18F-THK-5317
TJ Betthauser, PJ Lao, D Murali… - Journal of Nuclear …, 2017 - Soc Nuclear Med
This study compared the in vivo imaging characteristics of tau PET ligands 18 F-THK-5351
and 18 F-THK-5317 in the context of Alzheimer disease (AD). Additionally, reference tissue …
and 18 F-THK-5317 in the context of Alzheimer disease (AD). Additionally, reference tissue …
[HTML][HTML] Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population
…, PD Bulova, BJ Lopresti, RV Tumuluru, D Murali… - Alzheimer's & Dementia …, 2017 - Elsevier
Introduction Down syndrome (DS) arises from a triplication of chromosome 21, causing
overproduction of the amyloid precursor protein and predisposes individuals to early Alzheimer's …
overproduction of the amyloid precursor protein and predisposes individuals to early Alzheimer's …
Love to win or hate to lose? Asymmetry of dopamine D2 receptor binding predicts sensitivity to reward versus punishment
…, BT Christian, AS Fox, CR King, D Murali… - Journal of cognitive …, 2014 - direct.mit.edu
Humans show consistent differences in the extent to which their behavior reflects a bias
toward appetitive approach-related behavior or avoidance of aversive stimuli [Elliot, AJ …
toward appetitive approach-related behavior or avoidance of aversive stimuli [Elliot, AJ …
Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β‐amyloid accumulation
…, JM Oh, AT Hillmer, D Murali… - Alzheimer's & …, 2016 - Wiley Online Library
Introduction Biomarkers are urgently needed for the critical yet understudied preclinical
stage of Alzheimer's disease (AD). Methods Cerebrospinal fluid (CSF) collection, [C‐11]…
stage of Alzheimer's disease (AD). Methods Cerebrospinal fluid (CSF) collection, [C‐11]…
Dopamine asymmetries predict orienting bias in healthy individuals
…, BT Christian, AS Fox, CR King, D Murali… - Cerebral …, 2013 - academic.oup.com
Pseudoneglect is traditionally viewed as reflecting right hemisphere specialization for
processing spatial information, resulting in orienting toward the contralateral, left, hemispace. …
processing spatial information, resulting in orienting toward the contralateral, left, hemispace. …
Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity
…, SE Shelton, BT Christian, D Murali… - Journal of …, 2009 - Soc Neuroscience
The serotonin transporter (5-HTT) plays a critical role in regulating serotonergic neurotransmission
and is implicated in the pathophysiology of anxiety and affective disorders. Positron …
and is implicated in the pathophysiology of anxiety and affective disorders. Positron …