The mechanisms underlying the formation of acyl protein modifications remain poorly
understood. By investigating the reactivity of endogenous acyl-CoA metabolites, we found a class …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern
transmissibility, responsiveness to vaccination, and disease severity. In a screen for new …

Exposure to air pollutants, including particulate matter, results in activation of the brain
inflammatory response and Alzheimer disease (AD)-like pathology in dogs and humans. However…

Increasing NAD+ levels by supplementing with the precursor nicotinamide mononucleotide (NMN)
improves cardiac function in multiple mouse models of disease. While NMN …

10.7554/eLife.30057.001 daf-16/FoxO is required to survive starvation in Caenorhabditis
elegans, but how daf-16IFoxO promotes starvation resistance is unclear. We show that daf-16/…

The sirtuin enzymes are important regulatory deacylases in a variety of biochemical contexts
and may therefore be potential therapeutic targets through either activation or inhibition by …

… Briefly, 100 μL of acetonitrile and 100 μL of p-bromophenacyl-8 reagent were added to
the plasma extracts and the samples were vortex-mixed then incubated at 80C for 1 h with …

In mono-layered primary cell cultures baseline AMP and ADP levels are found nominally in
the mid to low picomolar range and are thus difficult to measure with conventional HPLC …

Millions of people worldwide are chronically exposed to arsenic through contaminated
drinking water. Despite decades of research studying the carcinogenic potential of arsenic, the …

The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor activates
cytoprotective and metabolic gene expression in response to various electrophilic stressors. …