β Barrel outer membrane proteins (OMPs) cluster into supramolecular assemblies that give
function to the outer membrane (OM) of Gram-negative bacteria. How such assemblies form …

Solute carrier spinster homolog 2 (SPNS2), one of only four known major facilitator superfamily
(MFS) lysolipid transporters in humans, exports sphingosine-1-phosphate (S1P) across …

The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we
identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide-major …

The T cell receptor (TCR-CD3) initiates T cell activation by binding to peptides of Major
Histocompatibility Complexes (pMHC). The TCR-CD3 topology is well understood but the …

The membrane-bound lymphocyte-specific protein-tyrosine kinase (Lck) triggers T cell
antigen receptor signalling to initiate adaptive immune responses. Despite many structure–…

Microbiology is traditionally considered within the context of wet laboratory methodologies.
Computational techniques have a great potential to contribute to microbiology. Here, we …

Influenza virion membrane molecular dynamics simulations at atomic resolution capture
surface protein vulnerabilities: implications for vaccine development.

Evidence from a range of experimental methods and molecular simulations has recently
revealed that the outer membrane of E. coli is phase-separated; there are regions that are …

Technology has been a part of everyone’s life for decades now, and its impact on our lifestyle
only seems to increase with time. Considering applications in the field of scientific research …

Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity,
and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associated with …