[HTML][HTML] Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015 …

A Cassini, LD Högberg, D Plachouras… - The Lancet infectious …, 2019 - thelancet.com
Background Infections due to antibiotic-resistant bacteria are threatening modern health
care. However, estimating their incidence, complications, and attributable mortality is …

[HTML][HTML] Burden of six healthcare-associated infections on European population health: estimating incidence-based disability-adjusted life years through a population …

A Cassini, D Plachouras, T Eckmanns, M Abu Sin… - PLoS …, 2016 - journals.plos.org
Background Estimating the burden of healthcare-associated infections (HAIs) compared to
other communicable diseases is an ongoing challenge given the need for good quality data …

[HTML][HTML] Prevalence of healthcare-associated infections, estimated incidence and composite antimicrobial resistance index in acute care hospitals and long-term care …

…, J Reilly, A Deptula, W Zingg, D Plachouras… - …, 2018 - eurosurveillance.org
Point prevalence surveys of healthcare-associated infections (HAI) and antimicrobial use in
the European Union and European Economic Area (EU/EEA) from 2016 to 2017 included …

Application of a loading dose of colistin methanesulfonate in critically ill patients: population pharmacokinetics, protein binding, and prediction of bacterial kill

AF Mohamed, I Karaiskos, D Plachouras… - Antimicrobial agents …, 2012 - Am Soc Microbiol
A previous pharmacokinetic study on dosing of colistin methanesulfonate (CMS) at 240 mg (3
million units [MU]) every 8 h indicated that colistin has a long half-life, resulting in …

Effect of clarithromycin in patients with sepsis and ventilator-associated pneumonia

…, JC Pechere, C Routsi, D Plachouras… - Clinical Infectious …, 2008 - academic.oup.com
Background . Because clarithromycin provided beneficiary nonantibiotic effects in
experimental studies, its efficacy was tested in patients with sepsis and ventilator-associated …

Evaluation of different laboratory tests for the detection of metallo-β-lactamase production in Enterobacteriaceae

…, PD Rekatsina, D Hatzaki, D Plachouras… - Journal of …, 2008 - academic.oup.com
Objectives Clinical isolates of Klebsiella pneumoniae (91), Escherichia coli (49), Enterobacter
spp. (27), Proteus mirabilis (17), Citrobacter freundii (2), Providencia stuartii (3) and …

[HTML][HTML] Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and …

D Plachouras, T Kärki, S Hansen, S Hopkins… - …, 2018 - eurosurveillance.org
Antimicrobial agents used to treat infections are life-saving. Overuse may result in more
frequent adverse effects and emergence of multidrug-resistant microorganisms. In 2016–17, we …

[HTML][HTML] Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection

…, K Papanikolaou, M Patrani, I Perdios, D Plachouras… - Critical Care, 2010 - Springer
Introduction Although major changes of the immune system have been described in sepsis,
it has never been studied whether these may differ in relation to the type of underlying …

[HTML][HTML] Contamination during production of heater-cooler units by Mycobacterium chimaera potential cause for invasive cardiovascular infections: results of an …

…, MA Sin, DL Monnet, D Plachouras… - …, 2016 - eurosurveillance.org
Invasive infections with Mycobacterium chimaera were reported in patients with previous
open chest surgery and exposure to contaminated heater-cooler units (HCUs). We present …

[HTML][HTML] Increasing number of cases and outbreaks caused by Candida auris in the EU/EEA, 2020 to 2021

A Kohlenberg, DL Monnet, D Plachouras… - …, 2022 - eurosurveillance.org
The number of cases of Candida auris infection or carriage and of countries reporting cases
and outbreaks increased in the European Union and European Economic Area during 2020 …