Broadly neutralizing hemagglutinin stalk-specific antibodies induce potent phagocytosis of immune complexes by neutrophils in an Fc-dependent manner
Broadly neutralizing antibodies that recognize the conserved hemagglutinin (HA) stalk have
emerged as exciting new biotherapeutic tools to combat seasonal and pandemic influenza …
emerged as exciting new biotherapeutic tools to combat seasonal and pandemic influenza …
IgA potentiates NETosis in response to viral infection
HD Stacey, D Golubeva, A Posca… - Proceedings of the …, 2021 - National Acad Sciences
IgA is the second most abundant antibody present in circulation and is enriched at mucosal
surfaces. As such, IgA plays a key role in protection against a variety of mucosal pathogens …
surfaces. As such, IgA plays a key role in protection against a variety of mucosal pathogens …
Reprogramming of acute myeloid leukemia patients cells: harboring cancer mutations requires targeting of AML hierarchy
D Golubeva, DP Porras, M Doyle… - Stem Cells …, 2023 - academic.oup.com
Screening of primary patient acute myeloid leukemia (AML) cells is challenging based on
intrinsic characteristics of human AML disease and patient-specific conditions required to …
intrinsic characteristics of human AML disease and patient-specific conditions required to …
[PDF][PDF] Sam68 allows selective targeting of human cancer stem cells
…, Z Shapovalova, J Russell, M Eguchi, D Golubeva… - Cell Chemical …, 2017 - cell.com
Targeting of human cancer stem cells (CSCs) requires the identification of vulnerabilities
unique to CSCs versus healthy resident stem cells (SCs). Unfortunately, dysregulated …
unique to CSCs versus healthy resident stem cells (SCs). Unfortunately, dysregulated …
[PDF][PDF] CXCL12/CXCR4 signaling enhances human PSC-derived hematopoietic progenitor function and overcomes early in vivo transplantation failure
Human pluripotent stem cells (hPSCs) generate hematopoietic progenitor cells (HPCs) but
fail to engraft xenograft models used to detect adult/somatic hematopoietic stem cells (HSCs) …
fail to engraft xenograft models used to detect adult/somatic hematopoietic stem cells (HSCs) …
[HTML][HTML] Developing CRISPR/Cas9-Mediated Fluorescent Reporter Human Pluripotent Stem-Cell Lines for High-Content Screening
…, M Nakanishi, D Porras, Y Kim, Z Feng, D Golubeva… - Molecules, 2022 - mdpi.com
Application of the CRISPR/Cas9 system to knock in fluorescent proteins to endogenous
genes of interest in human pluripotent stem cells (hPSCs) has the potential to facilitate hPSC-…
genes of interest in human pluripotent stem cells (hPSCs) has the potential to facilitate hPSC-…
[PDF][PDF] Human pluripotent stem cells identify molecular targets of trisomy 12 in chronic lymphocytic leukemia patients
Identifying precise targets of individual cancers remains challenging. Chronic lymphocytic
leukemia (CLL) represents the most common adult hematologic malignancy, and trisomy 12 (…
leukemia (CLL) represents the most common adult hematologic malignancy, and trisomy 12 (…
[HTML][HTML] Challenges in Cell Fate Acquisition to Scid-Repopulating Activity from Hemogenic Endothelium of hiPSCs Derived from AML Patients Using Forced …
DP Porras, JC Reid, B Tanasijevic, D Golubeva… - Cells, 2022 - mdpi.com
The generation of human hematopoietic stem cells (HSCs) from human pluripotent stem
cells (hPSCs) represents a major goal in regenerative medicine and is believed would follow …
cells (hPSCs) represents a major goal in regenerative medicine and is believed would follow …
3014–AN ENGINEERED FEEDER CELL-AND SERUM-FREE SYSTEM FOR THE EFFICIENT GENERATION OF CD19+ IGM+ B CELLS FROM HUMAN …
D Golubeva, S Babic, J Van Eyk, P Brauer, G Kuo… - Experimental …, 2021 - Elsevier
The ability to generate human B cells in vitro from CD34+ hematopoietic stem and progenitor
cells (HSPCs) facilitates studies of normal immune system development and disease …
cells (HSPCs) facilitates studies of normal immune system development and disease …
Fc-dependent effector functions of neutrophils induced by hemagglutinin stalk-specific antibodies
CE Mullarkey, MJ Bailey, D Golubeva… - The Journal of …, 2016 - journals.aai.org
Broadly neutralizing antibodies that recognize the conserved hemagglutinin (HA) stalk have
emerged as exciting new biotherapeutic tools to combat both seasonal and pandemic …
emerged as exciting new biotherapeutic tools to combat both seasonal and pandemic …