Senescence is the consequence of a signaling mechanism activated in stressed cells to
prevent proliferation of cells with damage. Senescent cells (Sncs) often develop a senescence-…

Physical function declines in old age, portending disability, increased health expenditures,
and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these …

Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

The impact of cellular senescence onto aging of organisms is not fully clear, not at least
because of the scarcity of reliable data on the mere frequency of senescent cells in aging tissues…

The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular
senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of …

While reports suggest a single dose of senolytics may improve vasomotor function, the
structural and functional impact of long‐term senolytic treatment is unknown. To determine …

Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction.
Telomere shortening and damage are recognized causes of cellular senescence and …

Telomeres are specialized nucleoprotein structures, which protect chromosome ends and
have been implicated in the ageing process. Telomere shortening has been shown to …

Senescent cells produce and secrete various bioactive molecules including interleukins,
growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has …

Chronic inflammation is associated with normal and pathological ageing. Here we show that
chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of …