User profiles for Diana R. Dou

Diana R. Dou

Stanford University
Verified email at stanford.edu
Cited by 265

Medial HOXA genes demarcate haematopoietic stem cell fate during human development

DR Dou, V Calvanese, MI Sierra, AT Nguyen… - Nature cell …, 2016 - nature.com
Pluripotent stem cells (PSCs) may provide a potential source of haematopoietic stem/progenitor
cells (HSPCs) for transplantation; however, unknown molecular barriers prevent the self-…

[HTML][HTML] Structural modularity of the XIST ribonucleoprotein complex

…, Y Wei, DR Dou, B Zarnegar, Q Ma, R Li… - Nature …, 2020 - nature.com
Long noncoding RNAs are thought to regulate gene expression by organizing protein complexes
through unclear mechanisms. XIST controls the inactivation of an entire X chromosome …

Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

…, RC Ransom, A Salhotra, SD Nagaraja, R Li, DR Dou… - Elife, 2020 - elifesciences.org
The Xist lncRNA mediates X chromosome inactivation (XCI). Here we show that Spen, an
Xist-binding repressor protein essential for XCI , binds to ancient retroviral RNA, performing a …

[PDF][PDF] Xist ribonucleoproteins promote female sex-biased autoimmunity

DR Dou, Y Zhao, JA Belk, Y Zhao, KM Casey, DC Chen… - Cell, 2024 - cell.com
Autoimmune diseases disproportionately affect females more than males. The XX sex
chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long non-…

[HTML][HTML] Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells

CS Grace, HKA Mikkola, DR Dou, V Calvanese… - Experimental …, 2018 - Elsevier
Highlights • We review the roles of retinoids in regulating hematopoietic stem cell (HSC)
specification and self-renewal. • Our results reconcile the contradictory results of previous …

[HTML][HTML] Zinc (Ii) and aiegens: The “clip approach” for a novel fluorophore family. A review

R Diana, B Panunzi - Molecules, 2021 - mdpi.com
… A systematic study of isomeric Schiff-base zinc complexes showing relevant differences in
their crystalline pattern and emission behaviour was published in 2018 by Rosita Diana and …

Distinct T cell chromatin landscapes in scleroderma subtypes

DR Dou, Y Zhao, B Abe, R Li, LC Zaba, K Aren… - bioRxiv, 2021 - biorxiv.org
Systemic sclerosis (SSc; scleroderma) is a poorly understood autoimmune rheumatic disease
that primarily affects women. The clinical hallmark is hardening of the skin, but internal …

[HTML][HTML] Inability to express HOXA cluster and BCL11A genes compromises self-renewal and multipotency of hESC-derived hematopoietic cells

DR Dou, A Minasian, MI Sierra, P Saarikoski, J Xu… - Blood, 2012 - Elsevier
Abstract 1190 The inability to derive functional hematopoietic stem cells (HSCs) in vitro from
pluripotent cells prevents widespread utilization of HSCs in the clinic; however, the …

Oral 5′-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study

…, A Ventura, M Stramba Badiale, R Diana… - Aging Clinical and …, 1993 - Springer
5′-Methyltetrahydrofolic acid (5′- MTHF) in addition to standard psychotropic medication
significantly improved clinical recovery in depressed patients with borderline or definite folate …

Medial HOXA gene expression is required for establishing “stemness” in human HSCs

DR Dou, V Calvanese, MI Sierra, R Sasidharan… - Experimental …, 2015 - exphem.org
The shortage in HLA-matched hematopoietic stem cells (HSCs) from bone marrow and cord
blood limits our ability to use HSC transplantation to treat blood and immune diseases. …