… In this study, Tavares-Ferreira et al. performed spatial single-cell transcriptomics in human
DRG neurons and compared the results with similar analysis in rodents and nonhuman …

Neuropathic pain is a leading cause of high-impact pain, is often disabling and is poorly
managed by current therapeutics. Here we focused on a unique group of neuropathic pain …

Nociceptors located in the trigeminal ganglion (TG) and DRG are the primary sensors of
damaging or potentially damaging stimuli for the head and body, respectively, and are key …

The SARS-CoV-2 virus infects cells of the airway and lungs in humans causing the disease
COVID-19. This disease is characterized by cough, shortness of breath, and in severe cases …

Background There are clinically relevant sex differences in acute and chronic pain
mechanisms, but we are only beginning to understand their mechanistic basis. Transcriptome …

Activation of the mechanistic target of rapamycin complex 1 (mTORC1) contributes to the
development of chronic pain. However, the specific mechanisms by which mTORC1 causes …

Originally identified in fibroblasts, Protease Inhibitor (PI)16 was recently shown to be crucial
for the development of neuropathic pain via effects on blood-nerve barrier permeability and …

Extrasynaptic α 5 ‐subunit containing GABA A (α 5 ‐GABA A ) receptors participate in chronic
pain. Previously, we reported a sex difference in the action of α 5 ‐GABA A receptors in …

Sex differences in gene expression are important contributors to normal physiology and
mechanisms of disease. This is increasingly apparent in understanding and potentially treating …

Peripheral sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG)
are specialized to detect and transduce diverse environmental stimuli including touch, …