User profiles for Diane Damotte
diane damotteVerified email at aphp.fr Cited by 19118 |
Immune infiltration in human cancer: prognostic significance and disease control
The interplay between tumors and their immunologic microenvironment is complex and difficult
to decipher, but its understanding is of seminal importance for the development of novel …
to decipher, but its understanding is of seminal importance for the development of novel …
The non–small cell lung cancer immune contexture. A major determinant of tumor characteristics and patient outcome
Solid tumors, beyond mere accumulation of cancer cells, form a complex ecosystem consisting
of normal epithelial cells, fibroblasts, blood and lymphatic vessels, structural components, …
of normal epithelial cells, fibroblasts, blood and lymphatic vessels, structural components, …
The immune microenvironment of human tumors: general significance and clinical impact
Human cancers grow in a microenvironment of stromal, inflammatory and immunocompetent
cells which is variable from tumor to tumor. The characterization of the immune contexture, …
cells which is variable from tumor to tumor. The characterization of the immune contexture, …
[HTML][HTML] Effector memory T cells, early metastasis, and survival in colorectal cancer
…, A Kirilovsky, M Nilsson, D Damotte… - New England journal …, 2005 - Mass Medical Soc
Background The role of tumor-infiltrating immune cells in the early metastatic invasion of
colorectal cancer is unknown. Methods We studied pathological signs of early metastatic …
colorectal cancer is unknown. Methods We studied pathological signs of early metastatic …
Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse.
Mice carrying a germ-line null mutation of the prolactin receptor gene have been produced
by gene targeting in embryonic stem cells. Heterozygous females showed almost complete …
by gene targeting in embryonic stem cells. Heterozygous females showed almost complete …
[HTML][HTML] Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
…, K Franciszkiewicz, D Damotte… - The Journal of …, 2012 - Am Soc Clin Investig
Appropriate localization and migration of T cells is a prerequisite for antitumor immune
surveillance. Studies using fixed tumor samples from human patients have shown that T cells …
surveillance. Studies using fixed tumor samples from human patients have shown that T cells …
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment
In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …
Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer
…, G Bizouard, P Validire, D Damotte… - American journal of …, 2014 - atsjournals.org
Rationale: It is now well established that immune responses can take place outside of
primary and secondary lymphoid organs. We previously described the presence of tertiary …
primary and secondary lymphoid organs. We previously described the presence of tertiary …
Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ …
Tumor-infiltrating T cells, particularly CD45RO + CD8 + memory T cells, confer a positive
prognostic value in human cancers. However, the mechanisms that promote a protective T-cell …
prognostic value in human cancers. However, the mechanisms that promote a protective T-cell …
Profound coordinated alterations of intratumoral NK cell phenotype and function in lung carcinoma
S Platonova, J Cherfils-Vicini, D Damotte, L Crozet… - Cancer research, 2011 - AACR
Both the innate and adaptive immune systems contribute to tumor immunosurveillance in
mice and humans; however, there is a paucity of direct evidence of a role for natural killer (NK) …
mice and humans; however, there is a paucity of direct evidence of a role for natural killer (NK) …