Identification of pancreatic cancer stem cells
Emerging evidence has suggested that the capability of a tumor to grow and propagate is
dependent on a small subset of cells within a tumor, termed cancer stem cells. Although data …
dependent on a small subset of cells within a tumor, termed cancer stem cells. Although data …
[PDF][PDF] Extracellular vesicle and particle biomarkers define multiple human cancers
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection.
We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in …
We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in …
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma
…, A Mehta, N Nabavizadeh, DM Simeone… - CA: a cancer journal …, 2020 - Wiley Online Library
Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer, the
prognosis for this disease remains very poor, largely because of delayed disease detection …
prognosis for this disease remains very poor, largely because of delayed disease detection …
Phenotypic characterization of human colorectal cancer stem cells
…, A Gurney, EH Huang, DM Simeone… - Proceedings of the …, 2007 - National Acad Sciences
Recent observations indicate that, in several types of human cancer, only a phenotypic
subset of cancer cells within each tumor is capable of initiating tumor growth. This functional …
subset of cancer cells within each tumor is capable of initiating tumor growth. This functional …
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
…, E Huang, E Finlayson, D Simeone… - Blood, The Journal …, 2009 - ashpublications.org
Th17 cells play an active role in autoimmune diseases. However, the nature of Th17 cells is
poorly understood in cancer patients. We studied Th17 cells, the associated mechanisms, …
poorly understood in cancer patients. We studied Th17 cells, the associated mechanisms, …
Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas
…, JC Devlin, M Baron, CH Hajdu, DM Simeone… - Nature …, 2020 - nature.com
Single-cell RNA sequencing (scRNA-seq) enables the systematic identification of cell
populations in a tissue, but characterizing their spatial organization remains challenging. We …
populations in a tissue, but characterizing their spatial organization remains challenging. We …
c-Met is a marker of pancreatic cancer stem cells and therapeutic target
…, B Sarkar, TH Welling, MP di Magliano, DM Simeone - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Growth of many different tumor types requires a population of self-renewing
cancer stem cells (CSCs). c-Met is a marker of normal mouse pancreatic stem and …
cancer stem cells (CSCs). c-Met is a marker of normal mouse pancreatic stem and …
Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma
Purpose: The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of pancreatic
adenocarcinoma and is upregulated in pancreatic adenocarcinoma cancer stem cells (…
adenocarcinoma and is upregulated in pancreatic adenocarcinoma cancer stem cells (…
Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer
CD Logsdon, DM Simeone, C Binkley, T Arumugam… - Cancer research, 2003 - AACR
The molecular basis of pancreatic cancer is not understood. Previous attempts to determine
the specific genes expressed in pancreatic cancer have been hampered by similarities …
the specific genes expressed in pancreatic cancer have been hampered by similarities …
Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment
Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …