User profiles for Dianfan Li
 | Dianfan LiShanghai Institute of Biochemistry and Cell Biology Verified email at sibcb.ac.cn Cited by 4103 |
Crystal structure of the integral membrane diacylglycerol kinase
Diacylglycerol kinase catalyses the ATP-dependent phosphorylation of diacylglycerol to
phosphatidic acid for use in shuttling water-soluble components to membrane-derived …
phosphatidic acid for use in shuttling water-soluble components to membrane-derived …
[HTML][HTML] Structure and mechanism of a group-I cobalt energy coupling factor transporter
Energy-coupling factor (ECF) transporters are a large family of ATP-binding cassette
transporters recently identified in microorganisms. Responsible for micronutrient uptake from the …
transporters recently identified in microorganisms. Responsible for micronutrient uptake from the …
Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers
…, S Li, F Qiao, L Yao, L Chen, G Ge, H Jiang, D Li, L Li… - Cell research, 2019 - nature.com
Breast cancer is a heterogeneous disease. In particular, triple-negative breast cancer (TNBC)
comprises various molecular subgroups with unclear identities and currently has few …
comprises various molecular subgroups with unclear identities and currently has few …
DHCR7: A vital enzyme switch between cholesterol and vitamin D production
The conversion of 7-dehydrocholesterol to cholesterol, the final step of cholesterol synthesis
in the Kandutsch-Russell pathway, is catalyzed by the enzyme 7-dehydrocholesterol …
in the Kandutsch-Russell pathway, is catalyzed by the enzyme 7-dehydrocholesterol …
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
…, N Van Eps, LN Caro, SA Vishnivetskiy, RJ Lee… - Nature, 2015 - nature.com
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin
binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-…
binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-…
Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes
The crystal structure of the β 2 -adrenergic receptor in complex with an agonist and its cognate
G protein has just recently been determined. It is now possible to explore in molecular …
G protein has just recently been determined. It is now possible to explore in molecular …
[HTML][HTML] Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure
determination of challenging membrane proteins. Here we present a technique for extruding …
determination of challenging membrane proteins. Here we present a technique for extruding …
Cholesterol homeostasis: How do cells sense sterol excess?
Cholesterol is vital in mammals, but toxic in excess. Consequently, elaborate molecular
mechanisms have evolved to maintain this sterol within narrow limits. How cells sense excess …
mechanisms have evolved to maintain this sterol within narrow limits. How cells sense excess …
Serial femtosecond crystallography of G protein–coupled receptors
X-ray crystallography of G protein–coupled receptors and other membrane proteins is hampered
by difficulties associated with growing sufficiently large crystals that withstand radiation …
by difficulties associated with growing sufficiently large crystals that withstand radiation …
[HTML][HTML] A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
T Li, H Cai, H Yao, B Zhou, N Zhang… - Nature …, 2021 - nature.com
SARS-CoV-2, the causative agent of COVID-19 1 , features a receptor-binding domain (RBD)
for binding to the host cell ACE2 protein 1 , 2 , 3 , 4 , 5 – 6 . Neutralizing antibodies that …
for binding to the host cell ACE2 protein 1 , 2 , 3 , 4 , 5 – 6 . Neutralizing antibodies that …