[HTML][HTML] The genetic architecture of structural left–right asymmetry of the human brain

Z Sha, D Schijven, A Carrion-Castillo, M Joliot… - Nature human …, 2021 - nature.com
Left–right hemispheric asymmetry is an important aspect of healthy brain organization for many
functions including language, and it can be altered in cognitive and psychiatric disorders. …

Mapping brain asymmetry in health and disease through the ENIGMA consortium

…, SR Mathias, D Van Rooij, D Schijven… - Human brain …, 2022 - Wiley Online Library
Left–right asymmetry of the human brain is one of its cardinal features, and also a complex,
multivariate trait. Decades of research have suggested that brain asymmetry may be altered …

Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals

Z Sha, A Pepe, D Schijven… - Proceedings of the …, 2021 - National Acad Sciences
Roughly 10% of the human population is left-handed, and this rate is increased in some
brain-related disorders. The neuroanatomical correlates of hand preference have remained …

[HTML][HTML] International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci

…, NL Saccone, SE Sanchez, D Schijven… - Nature …, 2019 - nature.com
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD …

[HTML][HTML] Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain …

Z Sha, D Schijven, C Francks - Molecular psychiatry, 2021 - nature.com
Autism spectrum disorder (ASD) and schizophrenia have been conceived as partly opposing
disorders in terms of systemizing vs. empathizing cognitive styles, with resemblances to …

Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling

D Schijven, D Kofink, V Tragante, M Verkerke… - Schizophrenia …, 2018 - Elsevier
Large-scale genome-wide association studies (GWAS) have implicated many low-penetrance
loci in schizophrenia. However, its pathological mechanisms are poorly understood, …

[HTML][HTML] Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

RL McLaughlin, D Schijven, W Van Rheenen… - Nature …, 2017 - nature.com
We have previously shown higher-than-expected rates of schizophrenia in relatives of patients
with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between …

Genetic architecture of the white matter connectome of the human brain

Z Sha, D Schijven, SE Fisher, C Francks - Science advances, 2023 - science.org
White matter tracts form the structural basis of large-scale brain networks. We applied brain-wide
tractography to diffusion images from 30,810 adults (UK Biobank) and found significant …

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

D Schijven, MC Postema… - Proceedings of the …, 2023 - National Acad Sciences
Left–right asymmetry is an important organizing feature of the healthy brain that may be
altered in schizophrenia, but most studies have used relatively small samples and …

Mid‐pregnancy corticotropin‐releasing hormone levels in association with postpartum depressive symptoms

…, C Hellgren, JD Olivier, D Schijven… - Depression and …, 2016 - Wiley Online Library
Background Peripartum depression is a common cause of pregnancy‐ and postpartum‐related
morbidity. The production of corticotropin‐releasing hormone (CRH) from the placenta …