[HTML][HTML] Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
F Saudou, S Finkbeiner, D Devys, ME Greenberg - Cell, 1998 - cell.com
The mechanisms by which mutant huntingtin induces neurodegeneration were investigated
using a cellular model that recapitulates features of neurodegeneration seen in Huntington's …
using a cellular model that recapitulates features of neurodegeneration seen in Huntington's …
Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats
G Imbert, F Saudou, G Yvert, D Devys, Y Trottier… - Nature …, 1996 - nature.com
Two forms of the neurodegenerative disorder spinocerebellar ataxia are known to be
caused by the expansion of a CAG (polyglutamine) trinucleotide repeat. By screening cDNA …
caused by the expansion of a CAG (polyglutamine) trinucleotide repeat. By screening cDNA …
The FMR–1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation
D Devys, Y Lutz, N Rouyer, JP Bellocq, JL Mandel - Nature genetics, 1993 - nature.com
Fragile X mental retardation syndrome is caused by the unstable expansion of a CGG
repeat in the FMR–1 gene. In patients with a full mutation, abnormal methylation results in …
repeat in the FMR–1 gene. In patients with a full mutation, abnormal methylation results in …
[HTML][HTML] LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation
…, CS Schmidt, S Krebs, M Zwerger, TV Cohen, D Devys… - Cell, 2013 - cell.com
Eukaryotic cells have a layer of heterochromatin at the nuclear periphery. To investigate
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …
Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias
Y Trottier, Y Lutz, G Stevanin, G Imbert, D Devys… - Nature, 1995 - nature.com
A POLYGLUTAMINE expansion (encoded by a CAG repeat) in specific proteins causes
neurodegeneration in Huntington's disease (HD) and four other disorders 1–6 , by an unknown …
neurodegeneration in Huntington's disease (HD) and four other disorders 1–6 , by an unknown …
Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form
Y Trottier, D Devys, G Imbert, F Saudou, I An, Y Lutz… - Nature …, 1995 - nature.com
Huntington's disease (HD) results from the expansion of a polyglutamine encoding CAG
repeat in a gene of unknown function. The wide expression of this transcript does not correlate …
repeat in a gene of unknown function. The wide expression of this transcript does not correlate …
[HTML][HTML] Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions
…, KS Lindenberg, L Ben-Haı̈em, C Weber, D Devys… - Molecular cell, 2002 - cell.com
Proteolytic processing of mutant huntingtin (mhtt) is regarded as a key event in the pathogenesis
of Huntington's disease (HD). Mhtt fragments containing a polyglutamine expansion …
of Huntington's disease (HD). Mhtt fragments containing a polyglutamine expansion …
[PDF][PDF] A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing
…, R Schüle, KI Takeyama, S Kato, L Tora, D Devys - Molecular cell, 2008 - cell.com
Transcriptional activators, several different coactivators, and general transcription factors are
necessary to access specific loci in the dense chromatin structure to allow precise initiation …
necessary to access specific loci in the dense chromatin structure to allow precise initiation …
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder caused by a CAG
repeat expansion in the SCA7 gene leading to elongation of a polyglutamine tract in ataxin-7, a …
repeat expansion in the SCA7 gene leading to elongation of a polyglutamine tract in ataxin-7, a …
The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription
The SAGA (Spt–Ada–Gcn5 acetyltransferase) coactivator complex contains distinct
chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of …
chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of …