Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration
correlates with lower patient survival and resistance to therapy. Tumor-associated …

This work identifies a novel lipid–associated macrophage subpopulation with immune
suppressive functions, offering new leads for therapeutic interventions in triple-negative breast …

Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates
with poor prognosis and is associated with local immunosuppression, which can be partly …

Recent advances in genome-wide analysis have revealed that 66% of the genome is actively
transcribed into noncoding RNAs (ncRNAs) while less than 2% of the sequences encode …

The triple-negative breast cancer (TN BC) subtype is the most aggressive form of invasive BC.
Despite intensive efforts to improve BC treatments, patients with TN BC continue to exhibit …

A significant proportion of patients with oestrogen receptor (ER) positive breast cancers (BC)
develop resistance to endocrine treatments (ET) and relapse with metastatic disease. Here …

Epithelial-to-mesenchymal transition-like (EMT-like) is a critical process allowing initiation of
metastases during tumour progression. Here, to investigate its role in intestinal cancer, we …

Background The present study focused on the prognostic roles of PIK3CA and PIK3R1 genes
and additional PI3K pathway-associated genes in breast cancer. Methods The mutational …

Concurrent chemoradiotherapy (CRT) with blockade of the PD-1 pathway may enhance
immune-mediated tumor control through increased phagocytosis, cell death, and antigen …

TTLL 3 and TTLL 8 are tubulin glycine ligases catalyzing posttranslational glycylation of
microtubules. We show here for the first time that these enzymes are required for robust …