User profiles for Didier Trono
 | Didier Tronoepfl Verified email at epfl.ch Cited by 79316 |
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
A retroviral vector system based on the human immunodeficiency virus (HIV) was developed
that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous …
that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous …
[HTML][HTML] Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study
Background Assessing the burden of COVID-19 on the basis of medically attended case
numbers is suboptimal given its reliance on testing strategy, changing case definitions, and …
numbers is suboptimal given its reliance on testing strategy, changing case definitions, and …
A third-generation lentivirus vector with a conditional packaging system
Vectors derived from human immunodeficiency virus (HIV) are highly efficient vehicles for in
vivo gene delivery. However, their biosafety is of major concern. Here we exploit the …
vivo gene delivery. However, their biosafety is of major concern. Here we exploit the …
[HTML][HTML] Dynamic control of endogenous retroviruses during development
HM Rowe, D Trono - Virology, 2011 - Elsevier
Close to half of the human genome encompasses mobile genetic elements, most of which
are retrotransposons. These genetic invaders are formidable evolutionary forces that have …
are retrotransposons. These genetic invaders are formidable evolutionary forces that have …
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene
therapy because they mediate the in vivo delivery and long-term expression of transgenes …
therapy because they mediate the in vivo delivery and long-term expression of transgenes …
Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery
In vivo transduction of nondividing cells by human immunodeficiency virus type 1 (HIV-1)-based
vectors results in transgene expression that is stable over several months. However, the …
vectors results in transgene expression that is stable over several months. However, the …
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.
We describe the construction of a safe, replication-defective and efficient lentiviral vector
suitable for in vivo gene delivery. The reverse transcription of the vector was found to be a rate-…
suitable for in vivo gene delivery. The reverse transcription of the vector was found to be a rate-…
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
…, P Turelli, G Caron, M Friedli, L Perrin, D Trono - Nature, 2003 - nature.com
Viral replication usually requires that innate intracellular lines of defence be overcome, a
task usually accomplished by specialized viral gene products. The virion infectivity factor (Vif) …
task usually accomplished by specialized viral gene products. The virion infectivity factor (Vif) …
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
The expression of genes delivered by retroviral vectors is often inefficient, a potential obstacle
for their widespread use in human gene therapy. Here, we explored the possibility that the …
for their widespread use in human gene therapy. Here, we explored the possibility that the …
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
Lentiviral delivery of glial cell line–derived neurotrophic factor (lenti-GDNF) was tested for
its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …
its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …