User profiles for Didong Li

Didong Li

Assistant Professor, Department of Biostatistics, Gillings School of Global Public Health …
Verified email at unc.edu
Cited by 239

[HTML][HTML] Alignment of spatial genomics data using deep Gaussian processes

A Jones, FW Townes, D Li, BE Engelhardt - Nature Methods, 2023 - nature.com
Spatially resolved genomic technologies have allowed us to study the physical organization
of cells and tissues, and promise an understanding of local interactions between cells. …

Estimating densities with non-linear support by using Fisher–Gaussian kernels

M Mukhopadhyay, D Li… - Journal of the Royal …, 2020 - academic.oup.com
Current tools for multivariate density estimation struggle when the density is concentrated
near a non-linear subspace or manifold. Most approaches require the choice of a kernel, with …

Probabilistic contrastive principal component analysis

D Li, A Jones, B Engelhardt - arXiv preprint arXiv:2012.07977, 2020 - arxiv.org
Dimension reduction is useful for exploratory data analysis. In many applications, it is of
interest to discover variation that is enriched in a "foreground" dataset relative to a "background" …

Alignment of spatial genomics and histology data using deep Gaussian processes

A Jones, FW Townes, D Li, BE Engelhardt - BioRxiv, 2022 - biorxiv.org
Spatially-resolved genomic technologies have allowed us to study the physical organization
of cells and tissues, and promise an understanding of the local interactions between cells. …

[PDF][PDF] Geodesic distance estimation with spherelets

D Li, DB Dunson - arXiv preprint arXiv:1907.00296, 2019 - arxiv.org
Many statistical and machine learning approaches rely on pairwise distances between data
points. The choice of distance metric has a fundamental impact on performance of these …

[HTML][HTML] 2D Dubins path in environments with obstacle

D Yang, D Li, H Sun - Mathematical Problems in Engineering, 2013 - hindawi.com
We recapitulate the achievement about the Dubins path as well as some precise proofs which
are important but omitted by Dubins. Then we prove that the shortest path ( -geodesic) in …

Contrastive latent variable modeling with application to case-control sequencing experiments

A Jones, FW Townes, D Li… - The Annals of Applied …, 2022 - projecteuclid.org
… Some covariance inequality tests have attempted to address the problem of highdimensional
data by using estimators of the distance between covariance matrices based on the …

Efficient manifold approximation with spherelets

D Li, M Mukhopadhyay… - Journal of the Royal …, 2022 - academic.oup.com
In statistical dimensionality reduction, it is common to rely on the assumption that high
dimensional data tend to concentrate near a lower dimensional manifold. There is a rich literature …

Inference for Gaussian processes with Matérn covariogram on compact Riemannian manifolds

D Li, W Tang, S Banerjee - Journal of Machine Learning Research, 2023 - jmlr.org
Gaussian processes are widely employed as versatile modelling and predictive tools in
spatial statistics, functional data analysis, computer modelling and diverse applications of …

[HTML][HTML] Absolute Winding Number Differentiates Mouse Spatial Navigation Strategies With Genetic Risk for Alzheimer's Disease

A Badea, D Li, AR Niculescu, RJ Anderson… - Frontiers in …, 2022 - frontiersin.org
Spatial navigation and orientation are emerging as promising markers for altered cognition
in prodromal Alzheimer’s disease, and even in cognitively normal individuals at risk for …