[HTML][HTML] DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex

P Ketterer, AN Ananth, DS Laman Trip, A Mishra… - Nature …, 2018 - nature.com
The nuclear pore complex (NPC) is the gatekeeper for nuclear transport in eukaryotic cells.
A key component of the NPC is the central shaft lined with intrinsically disordered proteins (…

Yeasts collectively extend the limits of habitable temperatures by secreting glutathione

DS Laman Trip, H Youk - Nature Microbiology, 2020 - nature.com
The conventional view is that high temperatures cause microorganisms to replicate slowly
or die. In this view, microorganisms autonomously combat heat-induced damages. However, …

[HTML][HTML] Slowest possible replicative life at frigid temperatures for yeast

DS Laman Trip, T Maire, H Youk - Nature Communications, 2022 - nature.com
Determining whether life can progress arbitrarily slowly may reveal fundamental barriers to
staying out of thermal equilibrium for living systems. By monitoring budding yeast’s slowed-…

Fundamental limits to progression of cellular life in frigid environments

DSL Trip, T Maire, H Youk - bioRxiv, 2022 - biorxiv.org
Life on Earth, including for microbes and cold-blooded animals, often occurs in frigid
environments. At frigid temperatures, nearly all intracellular processes slow down which is …

[HTML][HTML] A parallel algorithm for ridge-penalized estimation of the multivariate exponential family from data of mixed types

DS Laman Trip, WN Wieringen - Statistics and Computing, 2021 - Springer
Computationally efficient evaluation of penalized estimators of multivariate exponential
family distributions is sought. These distributions encompass among others Markov random …

A parallel algorithm for penalized learning of the multivariate exponential family from data of mixed types

DSL Trip, WN van Wieringen - arXiv preprint arXiv:1812.02401, 2018 - arxiv.org
Computational efficient evaluation of penalized estimators of multivariate exponential family
distributions is sought. These distributions encompass among others Markov random fields …

Cells collectively reshape habitability of temperature by helping each other replicate

DS Laman Trip, H Youk - bioRxiv, 2019 - biorxiv.org
How the rising global temperatures affect organisms is a timely question. The conventional
view is that high temperatures cause microbes to replicate slowly or die, both autonomously. …

[PDF][PDF] Evaluation of Schink et al.: Having the Gem Shine through a Fog

DSL Trip, T Maire, H Youk - Cell Systems, 2019 - cell.com
Laman Trip, Maire, and Youk blinded their identities during the peer review process but
have chosen to reveal them here. Schink et al. support the publication of this Peer Review; …

A parallel algorithm for penalized learning of the multivariate exponential family from data of mixed types

DS Laman Trip, WN van Wieringen - arXiv e-prints, 2018 - ui.adsabs.harvard.edu
Computational efficient evaluation of penalized estimators of multivariate exponential family
distributions is sought. These distributions encompass among others Markov random fields …

Secrete to beat the heat

KR Lauterjung, NM Morales, MN McClean - Nature Microbiology, 2020 - nature.com
Laman Trip and Youk’s results show that yeast are better equipped to survive high
temperatures when surrounded by neighbouring cells. This finding is surprising, because the …