Alzheimer's disease (AD) is associated with regional reductions in fluorodeoxyglucose
positron emission tomography (FDG PET) measurements of the cerebral metabolic rate for …

The apolipoprotein E (APOE) ɛ4 allele is the best established genetic risk factor for late-onset
Alzheimer's disease (LOAD). We conducted genome-wide surveys of 502,627 single-…

Epigenetic dysregulation of gene expression is thought to be critically involved in the
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation and …

DNA methylation is a vital component of the epigenetic machinery that orchestrates
changes in multiple genes and helps regulate gene expression in all known vertebrates. We …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression
that do not involve changes in the genotype. Epigenetics is of increasing relevance to …

DNA methylation [1] , [2] is capable of modulating coordinate expression of large numbers
of genes across many different pathways, and may therefore warrant investigation for their …

In this article, we have characterized and compared gene expression profiles from laser
capture microdissected neurons in six functionally and anatomically distinct regions from …

Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-causing
changes in phenotype by altering transcriptional activity in multiple genes spanning …

Brain deposits of amyloid β peptide (Aβ) have been a diagnostic hallmark of Alzheimer's
disease (AD) for nearly a century. Recent studies have demonstrated that Aβ is also present in …

Phagocytosis controls CNS homeostasis by facilitating the removal of unwanted cellular
debris. Accordingly, impairments in different receptors or proteins involved in phagocytosis …